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Dielectrophoretic Assembly of Functionalized Silica Nanoparticles and Its Effects on Dielectric Properties of Cells

Author: XuanFeng
Tutor: WangKeMin；TanWeiZuo
School: Hunan University
Course: Biomedical Engineering
Keywords: Dielectrophoresis Self-assembly Silica nanoparticles Sub-micron line , functional groups
CLC: TB383.1
Type: Master's thesis
Year: 2010
Downloads: 49
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Abstract


Microns or nano-structured precisely controllable and reversible self-assembly has great application prospects in the field of micro-nano biochemical sensing, a hotspot of recent years, the field of nanotechnology research. The dielectrophoretic technology is a promising nano-manipulation techniques, you can achieve the nanoparticles in microelectrode arrangement and operation of self-assembly. But by dielectrophoresis precise control of micro-and nano-assembly structure, there are still difficulties. In this thesis research objectives, phosphoric acid functional groups of the silica nanoparticles surface modified to achieve the self-assembled structures in the micro-electrode dielectrophoretic behavior of functionalized silica nanoparticles and its impact on the dielectric properties of cells precisely controllable and reversible. And functionalized silica nanoparticles by phagocytosis and its impact on the nature of the dielectric. The main work of this paper includes the following three aspects: 1, adopted by the different functional groups modified self-assembly behavior of silica nanoparticles dielectrophoresis, carboxylated silica nanoparticles of silica nanoparticles phosphorylation silica nano particles PEG silica nanoparticles and amino silica nanoparticles in self-assembly behavior of AC electric field dielectrophoresis visit, found functionalized groups with a strong negative charge modification can effectively enhance silica nanoparticles self-assembled on the microelectrode behavior. The reason is that the negatively charged functional group with strong the cation diffusion layer can enhance the surface of the silica nanoparticles, thereby improving its surface conductivity. It is targeted to improve the dielectric properties of nano-particles in aqueous solution to make it better the dielectrophoresis white assembled to provide a strong experimental basis. 2, based on the the dielectrophoresis real-time controllable, reversible silica fluorescence submicron line research on the basis of the first chapter, silica fluorescent nanoparticles phosphorylation of the object of study, by changing the frequency, electrode spacing factors dielectrophoretic behavior under ac electric field inspection of the system. Found this nano particles can be assembled into the inter-electrode spacing of 20pm the line fluorescence submicron. By controlling the electric field frequency to control the assembly of sub-micron line number, and the assembling of this sub-micron line structure is reversible. In addition, through the phosphorylation of the modified silica nanoparticles dispersed in different media, and found their dielectrophoretic behavior is sensitive to hydrogen ions in the dispersing medium. This part of the study show the potential applications of functionalized silica nanoparticles dielectrophoresis behavior. 3, different functional groups modified silica nanoparticles dielectric properties of cells in this chapter, different spacing fork electrode array as changes in cell dielectric properties distinguish tools, examine the different functions of the silica nanoparticles HeLa cells were incubated dielectric properties of cells. Found functionalized silica nanoparticles by HeLa cells engulf dielectrophoretic behavior and dielectric properties of the cells in the intracellular impact. The study is the first to investigate the impact of nanoparticles on the dielectric properties of cells, provides a method for tiny changes in the dielectric properties of cells.

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