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Study on Surface Modification of Magnesium Alloy and Its Corrision Resistance and Biocompatibility

Author: ZuoXiaoJing
Tutor: CaiKaiYong
School: Chongqing University
Course: Biology
Keywords: Magnesium alloy Corrosion-resistant 8 - hydroxyquinoline Cerium nitrate Biocompatibility
CLC: R318.08
Type: Master's thesis
Year: 2010
Downloads: 123
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Abstract


In this study, the layers of self-assembly technology to build a multi-layer film structure, the surface of the magnesium alloy designed to improve the corrosion resistance of magnesium alloy. Collected by hydrogen experiments, electrochemical impedance spectroscopy and polarization curves characterize the modified magnesium alloy corrosion resistance. The same time, characterized by cell proliferation and alkaline phosphatase detection cell compatibility of the modified magnesium alloy, magnesium alloy is used as a medical biomaterials provide experimental data. The main contents and results are as follows: preparation of the multilayer film structure in the surface of the magnesium alloy. Connected to the vacuum pump Spin-coater at 1000 rpm centrifugal force rotation 60 s, followed by PEI, PSS, 8HQ, PSS was spin coated onto the surface of magnesium alloy, and finally formed AZ91D / (PEI/PSS/8HQ/PSS) 25. Sequentially using the same method as PEI, GEL, Ce, gel spin coating to the surface of the magnesium alloy, and finally the formation of AZ91D / (PEI/GEL/8HQ/GEL) 25. Spin-coater rotation formed by coating the surface of the magnesium alloy the AZ91D / (PEI/PSS/8HQ/PSS) 25 anti-corrosion coatings with 5% glutaraldehyde cross-linked 20 min using Fourier transform infrared spectroscopy characterization. The results showed that 8-HQ multilayer film between the crosslinked, improve the stability of the multilayer film. Scanning electron microscopy and energy dispersive spectroscopy for characterization of the the 8-HQ multilayer film in the m-SBF soaking after a certain time, the surface morphology and elemental composition. The results showed that 8-HQ multilayer film modified glutaraldehyde magnesium alloy surface damage minimum 8-HQ multilayer film modified magnesium alloy after soaked in m-SBF, P, Cl solution and Ca ions participate in the corrosion reaction and immersed and adsorption in the the AZ91D substrate corrosion precipitate layer in. Hydrogen release assay multilayer film modified magnesium alloy degradation behavior of different samples by 7 days soaking in the m-SBF, 8-HQ multilayer film modified glutaraldehyde magnesium alloy after hydrogen release minimum. The results show that the the glutaraldehyde crosslinked 8-HQ modified multilayer film corrosion resistance of magnesium alloy with compared to Blank magnesium alloy, improve. Electrochemical impedance spectroscopy and polarization curves of multilayer films modified magnesium alloy corrosion resistance in m-SBF solution. The results show that the modified magnesium alloy in the multilayer film having a better corrosion resistance. The rotation of the spin-coater coating the surface of the magnesium alloy is formed AZ91D / (PEI / GEL / Ce / GEL) 25 anti-corrosion film, and washed with 5% glutaraldehyde crosslinked 20 min. The contact angle tester monitor the assembly process of the of cerium multilayer film on the surface of magnesium alloy. The results show that, (PEI / GEL / Ce / GEL) 25 in the magnesium alloy surface uniform film. Electrochemical impedance spectroscopy and polarization curves of cerium multilayers modified magnesium alloy corrosion resistance in m-SBF solution. The results show that the cerium multilayer film modified magnesium alloy having a better corrosion resistance. In vitro culture SD neonatal rat osteoblast, and poor adherence to its effective purification. Morphology and calcium nodule staining that has typical biological behavior of osteoblasts. Cells after subculture to the third generation for subsequent cell compatibility test. Spin-coater rotation formed by coating the surface of the magnesium alloy AZ91D / (PEI/PSS/8HQ/PSS) Preparation of conditioned medium of the 25 anti-corrosion coatings, different treatment of magnesium alloy 24 h soaked with DMEM medium (high glucose), draw culture medium, with a high-speed centrifuge, the supernatant as conditioned medium, characterization of the cell proliferation activity (MTT) and alkaline phosphatase (ALP). The results show that the multilayer film modified magnesium alloy has good cell compatibility. Spin-coater rotation formed by coating the surface of the magnesium alloy AZ91D / (PEI / GEL / Ce / GEL) Preparation of conditioned medium of the 25 anti-corrosion coatings, different treatment of magnesium alloy 24 h soaked with DMEM medium (high glucose), draw culture medium, with a high-speed centrifuge, the supernatant as conditioned medium, characterization of the cell proliferation activity (MTT) and alkaline phosphatase (ALP). The results show that the multilayer film modified magnesium alloy has good cell compatibility.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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