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The Clinic Curative Effect Observation of Qi Zhu Prescription Treating to PLGC and Experimental Study of the Anti-tumor Mechanism of AstragalosideIV and β-elemene

Author: CaoLiPing
Tutor: ShenHong
School: Nanjing University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: Qizhu party Precancerous lesions Astragaloside β - elemene Cyclooxygenase Vascular endothelial growth factor Prostaglandin E2
CLC: R273
Type: Master's thesis
Year: 2010
Downloads: 126
Quote: 0
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Abstract


Clinical efficacy ; purpose observation Qizhu side of precancerous lesions the Astragaloside , β- elemene from the perspective of molecular biology to explore its synergistic mechanism of anti-tumor compatibility of gastric cancer cells SGC7901 . Method clinical part : randomized controlled method , 50 cases of 50 cases of gastric precancerous lesions of 100 patients were randomly divided into treatment group and control group , the treatment group taking Qizhu side , the control group taking Weifuchun course of treatment was 3 months , the symptoms and pathological grading quantify , to determine the treatment effect ; experimental part : using the MTT assay observation Astragaloside β - elemene inhibition of SGC-7901 gastric cancer cells by RT-PCR and Western blot method of dosing descendants of gastric cancer cells of COX- 2 gene and its protein expression changes in human gastric cancer cell medium was measured by ELISA VEGF of PGE2 content . The results of the clinical part : The results showed that the treatment group improved epigastric pain , fullness , body tired fatigue , appetite decreased , belching symptoms than the control group , between two groups was statistically significant ( P lt; 0.05 ) . The treatment group syndromes total score compared with control group was statistically significant (P lt; 0.05), and markedly effective rate of the treatment group than the control group ( P lt; 0.01 ) ( 84 % VS60.0 % ) . Patients can improve gastric mucosal atrophy , intestinal metaplasia , dysplasia , its group differences were statistically significant ( P lt; 0.05 ) after treatment . Experimental part: Astragaloside , β- elemene can inhibit the growth of human gastric cancer cells , showed a dose-effect relationship ; human gastric cancer cells can inhibit COX-2 gene and protein expression , and can reduce VEGF in human gastric cancer cell culture medium , PGE2 content . The side of conclusions Qizhu valid prescription for the treatment of precancerous lesions . Its mechanism of action may be through inhibition of COX -2 , thereby inhibiting the expression of the downstream product PGE2 and VEGF downregulation , thereby inhibiting tumor growth .

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