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Glucose Transporter Protein 1 in Human Laryngeal Squamous Cell Carcinoma of the Preliminary Study

Author: JiangJianGuo
Tutor: HuGuoHua
School: Chongqing Medical University
Course: Otorhinolaryngology
Keywords: Laryngeal squamous cell carcinoma Glucose transporter protein 1 Immunohistochemistry Reverse transcriptase polymerase chain reaction
CLC: R739.65
Type: Master's thesis
Year: 2010
Downloads: 10
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Abstract


Objective To observe the glucose transporter protein 1 (glucose transporter 1, GLUT1) expression in human laryngeal squamous cell carcinoma and its relationship with clinical pathology ; investigate GLUT1 laryngeal lymphatic metastasis . Methods immunohistochemistry and reverse transcription - polymerase chain reaction ( RT - PCR ) method detected 57 cases of patients with laryngeal squamous cell carcinoma tumor tissue , laryngeal tissue paracancerous and away from the tumor normal laryngeal tissue GLUT1 protein and mRNA expression , and combined with the clinical and pathological features of patients with laryngeal cancer were analyzed ; VEGFR-3 labeled by immunohistochemical methods , lymphatic vessels , analysis of GLUT1 laryngeal lymphatic metastasis . Results (1) GLUT1 immunohistochemistry of : of GLUT1 expression in laryngeal carcinoma than the throat tissue next to the cancer and normal laryngeal tissue ( P lt; 0.01 ) higher than that of well-differentiated carcinoma (P ; expression in poorly differentiated laryngeal = 0.043 ) ; compared ⅰ phase II laryngeal phase III IV laryngeal high expression of GLUT1 trend (P = 0.003); expression of laryngeal cancer with lymph node metastasis than those without lymph node metastasis of laryngeal cancer ( P = 0.021 ) ; expression in tumors ≥ 3cm in diameter than the diameter of lt ; 3cm tumor (P = 0.032). (2) RT-PCR results : GLUT1 expression in laryngeal carcinoma than the throat tissue next to the cancer and normal laryngeal tissue ( P lt; 0.01 ) ; significantly higher than that in poorly differentiated laryngeal moderately differentiated and well-differentiated carcinoma (P = 0.026); compared ⅰ phase II laryngeal phase III IV laryngeal high expression of GLUT1 trend (P = 0.018); expression of laryngeal cancer with lymph node metastasis than those without lymph node metastasis of laryngeal cancer ( P = 0.04); expression in tumor ≥ 3 cm in diameter than the diameter lt ; 3 cm tumor ( P = 0.048 ) . (3) VEGFR-3 immune staining : expression in laryngeal carcinoma than the laryngeal tissue paracancerous and normal laryngeal tissues ( P lt; 0.01 ) ; expression of laryngeal carcinoma lymph node metastasis than those without lymph node metastasis in laryngeal cancer (P = 0.012). Conclusion GLUT1 laryngeal development, differentiation, lymph node metastasis, prognosis is closely related , can be used as laryngeal cancer diagnosis and treatment , the prognosis is one of the indicators .

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CLC: > Medicine, health > Oncology > Department of Otolaryngology tumor > Laryngeal tumors
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