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Absolute Quantification of Brain Metabolite Concentration in Precentral Gyrus and Hippocampus of Healthy Adults Using Proton Magnetic Resonance Spectroscopy and LCModel

Author: ChengXiaoFang
Tutor: WuRenHua
School: Shantou University
Course: Medical Imaging and Nuclear Medicine
Keywords: Proton magnetic resonance spectroscopy Brain metabolites Quantitative LCModel
CLC: R445.2
Type: Master's thesis
Year: 2010
Downloads: 31
Quote: 0
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Abstract


Objective: This study by proton magnetic resonance spectroscopy (1H-MRS) technology combined with LCModel software to analyze the characteristics of the concentration of brain metabolites in normal healthy adult central gyrus and hippocampus . Methods : 14 normal healthy volunteers , nervous system disease history . Superconducting magnetic resonance scanner with GE1.5T Signa HDX stimulus the echo sampling mode (STEAM) measured the brain, the left medial frontal gyrus and hippocampus brain metabolites repeat time ( TR ) 3000 ms , the sequence echo time (TE) 20ms, and carried out on the acquired data post-processing and quantitative analysis using LCmodel software . Determination of metabolites include N-acetyl- aspartic acid ( NAA ) , creatine compound was ( Cr ) the choline substance ( Cho ) , myo-inositol ( MI ) , glutamine and glutamic acid composite (GLU GLN). Results : paired samples t test results show Central before back and hippocampus of the brain metabolic substance concentration exists differences , hippocampus compared with precentral back to contain than significant with high concentrations of Cho and MI ( P lt ; 0.01 ) , while NAA concentration than the central gyrus low (p lt ; 0.05) , no statistical difference in the two parts of the Cr and GLX concentration ; linear regression analysis showed that the two parts of central gyrus and hippocampal NAA and Cr concentrations exists a linear relationship . Conclusion : former central brain metabolite concentration difference between the back and the hippocampus . Linear correlation between the two parts , part of the brain metabolites and Cr .

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CLC: > Medicine, health > Clinical > Diagnostics > Diagnostic Imaging > Magnetic resonance imaging
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