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Objective: This topic To further elucidate the soup of Angelica twist pain of rheumatoid arthritis treatment effect, the use of adjuvant arthritis model in rats, after treatment by different doses of Angelica twist pain soup through detection of matrix metalloproteinase-3, C-reactive protein, ESR, joint pain index, weight and other indicators of changes designed to explore the early control of disease progression valid prescription, and further improve the degree of understanding of the indicators and symptoms of different doses the Angelica twist pain soup for rheumatoid arthritis. Methods: (1) select 60 Wistar rats, male, according to the random number table is divided into blank group, model group, Angelica twist pain the soup low dose group, middle dose group of Angelica twist pain soup, Angelica cast pain the soup high dose group (n = 12), and No. In addition to the control group, each rat right hind toe intradermal injection of complete Freund's adjuvant 0.1ml proinflammatory. (2) in modeling two weeks, all rats were taken gavage administration of a total of 18 days, the the Blank group and the model group were given distilled water. (3) general modeling before and after treatment the rats, recording weight, cause inflammation at different times after the ankle joint swelling, joint pain index, measured with Westergren erythrocyte sedimentation rate, measured by ELISA matrix metal proteinase 3 C-reactive protein, and take the right ankle fixed, decalcified, embedded in paraffin, HE staining, light microscopy of articular pathological changes. (4) Application SPSS13.0 statistical software for statistical analysis. Results: (1) matrix metalloproteinase-3, C, reactive protein, erythrocyte sedimentation rate in dose group and high dose group showed no statistical significance (P gt; 0.05) in the high dose group and low dose group, model group were statistical significance (P lt; 0.05). (2) caused by inflammation at different times after ankle swelling and joint pain index changes in treatment methods and treatment time interaction; high-32d, the middle dose group and low dose group, model group, a statistically significant difference ( P lt; 0.01); high-dose group, middle dose group showed no significant differences (P gt; 0.05). (3) caused by inflammation at different times after changes in body weight in the therapeutic effect of the treatment time interaction; to 32d in dose group and the model group, low-dose group, high dose group was statistically significant (P lt; 0.01). (4) Angelica twist pain soup certainly inhibit synovial damaging effects, which Angelica twist pain soup in the high-dose group were significantly lower doses. Conclusion: (1) Angelica twist pain soup, middle dose group with a good anti-inflammatory and analgesic effects. (2) Angelica twist pain soup certainly inhibit synovial damaging effects, which Angelica twist pain soup in the high-dose group were significantly lower doses. (3) Angelica twist pain soup dose rats weight significantly increased body weight compared to other model rats, indicating that the original dose of the party is good to reconcile the role of the spleen and stomach, the Chinese stomach is the source of qi and blood, does have practical significance.
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