Dissertation > Excellent graduate degree dissertation topics show

Correlation Studies of Plasma Fatty Acids and Type 2 Diabetes Mellitus: Case Control Study

Author: ShouTianXing
Tutor: LiZuo
School: Zhejiang University
Course: Food Engineering
Keywords: type 2 diabetes mellitus plasma phospholipid fatty acids plasma triglyceride fatty acids plasma total fatty acids
CLC: R587.1
Type: Master's thesis
Year: 2012
Downloads: 16
Quote: 0
Read: Download Dissertation

Abstract


Epidemiological survey from 2007to 2008 showed that morbidity rate of diabetes of adults over the age of 20 is 9.7% and of which type 2 of diabetes mellitus (T2DM) accounted for 90.0%. The increasing incidence of T2DM year by year is closely related to dietary factors. Because of the complexity of Chinese diet and the arbitrary during cooking process, it’s difficult to study the interaction between daily nutritional intake and T2DM through analysis of dietary components. We choose plasma fatty acid as a biological marker of dietary fat intake. The plasma fatty acids of T2DM group and control group were determined and then used for the analysis of interaction relationship. We collected 214 volunteers including 104 T2DM patients and 110 healthy people.Results:Overall, age, blood pressure, A1C、FPG、LDL-C、HCY, VB12 and FOL were significantly higher in T2DM subjects than in control subjects. Height, weight, ALB and TC were lower in T2DM subjects than in control subjects. Though there is some difference between male and female, they showed a similar trend. In plasma phospholipid fatty acids:Percentage of Total PUFA were significantly higher in T2DM subjects than in control subjects, while male T2DM subjects had a significant lower SFA and no difference in female. But female T2DM subjects had higher C20:3n-6 and C20:4n-6. Pearson correlation analysis showed Total SFA was with TC and TG, while PUFA was negatively correlated with TC. Except the positive relationship between C18:0 and TG existed in T2DM group and control group meanwhile, C14:0、C14:1、C16:1、C18:0、C18:1n-7、C20:1、C20:2n-6、C20:3n-6、C22:2n-6、C22:4n-6、Total SFA all had different correlations in two groups. MUFA was positively correlated with HCY while total PUFA was negative with it. HCY was only negative corrected with DHA and C22:1 in control group. But there were many fatty acids which have significant correlation with it in T2DM group. In plasma triglyceride fatty acids:male subjects in T2DM group had significant higher PUFA and n-6 PUFA. Though there was no significance in female subjects, there was still some increase of PUFA and n-6 PUFA. In plasma total fatty acids:except for female’s higher SFA and lower n-6 PUFA than the control group, there was no other significant difference. Also there was no significance in logistic regression analysis.Conclusions:there is a significant difference of plasma fatty acids component between T2DM patients and healthy people Plasma phospholipid, triglyceride and total fatty acid composition were not identical. Plasma phospholipid had more strong relationship with various indexes than the other two. T2DM patients had higher sensitivity and were more easily affected by different fatty acid intake than healthy people. The unsaturated fatty acid can reduce blood HCY content in T2DM patients but no use for healthy ones.

Related Dissertations

  1. Relationship between Level of Serum Uric Acid and Lower Extremity Arterial Disease in Patients with Type 2 Diabetes Mellitus,R587.1
  2. Efficacy and Safety of Biphasic Insulin Aspart 30 Once-daily Treatment in Patients with Type 2 Diabetes,R587.1
  3. The Blood Glucose Control and Influencing Factors in Type 2 Diabetic Patients with Oral Hypoglycemic Agents,R587.1
  4. Association of Genetic Variation of UTS2 Gene with Type2 Diabetes Mellitus and Hypertension,R587.1
  5. Effect of Gastric Bypass on the Blood Glucose Level in Type 2 Diabetes Rat Model,R587.1
  6. Relationship between Postprandial Blood Pressure and Lower Extremity Arterial Disease in Patients with Type 2 Diabetes Mellitus,R587.1
  7. The Comparison of Therapeutic Effect and Security between CSⅡ and MDI in Type 2 Diabetes Mellitus,R587.1
  8. The Characteristics of Coronary Angiography in Type 2 Diabetes Mellitus Patients with Suspected Coronary Artery Disease,R587.1
  9. Effect of Whey Protein on Improving Insulin Resistance and the Underlying Mechanisms,R587.1
  10. The Changes of T Lymphocyte Subsets and Costimulatory Molecules Before and After Shuxuetong Treatment in Type 2 Diabetes Subjects with Diabetic Kidney Disease,R692
  11. 50 Cases of Type 2 Diabetic Patients Serum Trace Element and Vitamin Change Analysis,R587.1
  12. Risk Factors and Their Interaction of Type 2 Diabetes Mellitus among Rural Residents in Wang Cheng,R587.1
  13. Effects of New Intravenous Infusions on Blood Glucose Variability in Elderly Type 2 Diabetic Patients,R587.1
  14. Clinical Observation on the Efficacy and Safety of Biphasic Insulin Aspart 30 for the Treatment of 234 Patients with Type 2 Diabetic,R587.1
  15. Comparison of Differences in Bone Mineral Density and Its Related Factors for Patients with Type 2 Diabetes Mellitus of Han, Uygur Nationalities in Xinjiang,R587.1
  16. Energy Supply and Nutritional Intervention Study in Hospitalized Patients with Type 2 Diabetes,R587.1
  17. Expression of Chemerin in Liver of Diet Induced Type 2 Diabetic Rats with IL-6 Intervention,R587.1
  18. Influence of Rosiglitazone on Both Bone Mineral Bensity and the Expression of BMP-2 and Bcl-xL in Osteoblast in OLETF Rats,R587.1
  19. Huanglianjiedu Tonga flavor particles combined basal insulin , metformin onset obesity, type 2 diabetes clinical observation,R587.1
  20. The Clinical Study with Exenatide in Patients of Overweight of Obesity with Type 2 Diabetes Mellitus Inadequately Controlled in Blood Glucose,R587.1

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
© 2012 www.DissertationTopic.Net  Mobile