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By detecting epithelial type calcium adhesion proteins (E-Cadherin; E-cad) and apoptosis-related protein of Survivin of Fas expression in gastric cancer tissue and normal tissue, and gastric carcinoma E-Cad protein, Survivin protein The correlation between the Fas protein analysis, to explore the relationship between E-Cad and apoptosis of gastric carcinoma. The continuous collection Changzhi Medical College and Ji Hospital gastric resection tissue samples after 63 cases, 22 cases of well-differentiated groups, differentiated group of 20 cases, 22 cases of poorly differentiated group of 21 patients and a control group of normal gastric mucosa. 10% neutral formalin-fixed, paraffin-embedded, sliced, Immunohistochemical detection of E-cad protein, Survivin protein, Fas protein targets, correlation analysis of the data, the statistical relationship between picture analyzer. Results 1 gray value of E-cadherin protein expression in normal gastric tissue and high, medium, poorly differentiated gastric adenocarcinoma group were: 59.40 ± 36.235,161.33 ± 14.908,177.67 ± 14.583,193.73 ± 38.145; of Fas protein in normal stomach tissue and high gray values ??expressed in poorly differentiated gastric adenocarcinoma group were 107.60 ± 41.684,150.67 ± 14.927,166.47 ± 13.907,183.33 ± 30.928; of Survivin protein in normal gastric tissue and high in poorly differentiated gastric adenocarcinoma gray values ??expressed in the cancer group were 162.40 ± 35.924,71.60 ± 14.126,56.60 ± 17.283,62.27 ± 29.666. 2, E-cad protein, Fas protein expression in normal gastric tissue were higher than the expression of gastric adenocarcinoma group (P lt; 0.05); highly differentiated gastric adenocarcinoma with poorly differentiated adenocarcinoma group compared differences (P lt; 0.05); However, the high, moderately differentiated adenocarcinoma, but there was no difference in sex (P gt; 0.05); Survivin protein expression in gastric adenocarcinoma is higher than normal gastric tissues in the different degree of differentiation of gastric adenocarcinoma were no differences in sex (P gt; 0.05). 3, high, medium, poorly differentiated gastric adenocarcinoma group of E-cad protein expression of Fas protein expression, have a correlation (P lt; 0.05), correlation coefficients were r = 0.973, r = 0.915 and r = = 0.977, respectively,; high , poorly differentiated gastric adenocarcinoma group of E-cad protein expression of Survivin protein expression compared were correlated, the correlation coefficient r = -0.959, r = -0.915, r = -0.991. Conclusion 1, E-Cad protein expression levels in gastric adenocarcinoma tissue differentiation degree of. Expression of Survivin protein in gastric adenocarcinoma increased, suggesting that its associated with gastric cancer, but it has nothing to do with the degree of tumor differentiation. Of Fas protein expression in gastric adenocarcinoma reduce prompted with gastric cancer, and gastric tissue differentiation. E-cad protein Survivin protein expression was negatively correlated with the expression of Fas was positively correlated. Tip E-cad may stimulate tumor cell apoptosis abnormal, resulting in the generation of the tumor.
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