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Gene Diagnosis of Mig-7 of Micrometastases in Lymph Nodes and Peripheral Blood in Patients with Lung Cancer and Its Clinical Significance

Author: YanHuiZhi
Tutor: WangJianJun
School: Huazhong University of Science and Technology
Course: Thoracic Surgery
Keywords: Lung cancer Micrometastasis Mig-7 RT-PCR Lymph node Peripheral blood
CLC: R734.2
Type: Master's thesis
Year: 2011
Downloads: 7
Quote: 0
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Abstract


Objective To explore the clinical significance of gene diagnosis in detecting micrometastases in lung cancer by detecting Mig-7 mRNA expression in lymph nodes and peripheral blood.Methods The Mig-7 mRNA expression was detected in lesions, lymph nodes and peripheral blood from 30 lung cancer patients and 10 benign pulmonary lesion patients, and in the blood samples from 8 healthy volunteers by RT-PCR.Results The positive rates of Mig-7 mRNA expression were 77%, 51% and 27% in cancer tissues, lymph nodes and peripheral blood from lung cancer patients respectively. No Mig-7 mRNA was expressed in lesions, lymph nodes and peripheral blood from the patients with benign pulmonary lesions or in the peripheral blood from the volunteers.Conclusion The detection of Mig-7 mRNA in lymph nodes and peripheral blood from lung cancer patients by RT-PCR might be beneficial for diagnosing micrometastases early, identifying the stage, and providing important information in the selection of appropriate treatment strategies and for the evaluation of prognosis.

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CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
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