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Objectives: To investgate the expression of members of human chitinase family of AMCase ,Chitotriosidase(CHIT-1) ,SI-CLP(CHID-1) ,Chi3l1,CTBS and Oviductal Glycoprotein 1(OVGP-1)And compare its expression in normal nasal mucosa,chronic rhinosinusitis(CRS)and nasal polyps (NPs)。Method: The study group consisted of 9 samples with CRSwNPs ,9 samples with CRSsNP and 10 control subjects of inferior turbinate tissues (ITTs).Real-time polymerase chain reactions were performed to quantify mRNA expression levels.Results : AMCase ,CHIT-1 ,SI-CLP ,Chi3l1 and OVGP-1 were expressed in the groups;CTBS expression 20%(2?10)in ITTs,33%(3?9)in CRS and 33% (3?9)in NPs.AMCase and Chi3l1 expressions in NPs were 2.4 folds(P=0.008)and 2.16 folds(P=0.03)compared with ITTs respectively.In ITTs group,there was a positive correlation between CHIT-1 and SI-CLP expression (r = 0.76, P=0.0092),Chi3l1 (r = 0.63, P=0.0479)and OVGP-1(r = 0.87879, P= 0.0008) respectively and Chi3l1 and OVGP-1 (r = 0.67, P=0.033).In CRS, positive correlation between CHIT-1 and SI-CLP expression (r = 0.76, P=0.015),Chi3l1(r = 0.66 ,P=0.0499) , AMCase(r = 0.73, P=0.0246)and OVGP-1(r = 0.93, P=0.0002) respectively.SI-CLP and AMCase (r =0.70, P=0.0358). AMCase and OVGP-1(r = 0.7, P=0.0358). In NPs, positive correlation between expression of CHIT-1 and Chi3l1(r=0.81,P=0.007) ,CHIT-1 and OVGP-1 expression(r=0.68, P=0.042); AMCase and Chi3l1 expression(r =0.66, P=0.049); AMCase and OVGP-1 expression (r =0.71,P=0.0298).Conclusion: This study showed the presence of AMCase,CHIT1 mRNA and other members of chitinase family in normal and inflammatory states of nasal and sinuses。The positive correlation of the signficant coexpression of some members in normal and inflammatory states of nasal and sinuses.
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