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Objective: To investigate leptin (Leptin) levels in patients with type 2 diabetes Yunnan bone mineral density and osteoporosis correlation. Methods: 239 patients with type 2 diabetes mellitus (T2DM group), 287 healthy controls (NC group). Serum leptin was measured in both groups, FPG, insulin, C-peptide, lipids, hormones, PTH, HbA1c, and DEXA bone density measured. Results: ① two individuals: age, weight, height, BMI, WHR, BP (SBP, DBP), HDL-C, FPG, UA, AST, BUN there are significant differences. ② In the NC group: Serum leptin levels and TC, HDL-C was [positive correlation (P lt; 0.05). In T2DM group, serum leptin levels and BMI, WC, 120min C-peptide, there was a positive correlation (P lt; 0.05), and height, E2 negatively correlated (P lt; 0.05). ③ T2DM group body BMD values of BMI, E2 was [positively correlated with PTH was negatively correlated. L1-4 BMD values of FPG, E2 was [positively correlated with PTH was negatively correlated. NC group L4 BMD and BMI, WC, WHR, UA was [positively correlated with TG, HDL-C was negatively correlated. Body BMD values with WC, WHR, SBP, UA was positively correlated with TC, HDL-C was negatively correlated. ④ T2DM group of women Leptin levels were significantly higher than men (P lt; 0.001). ⑤ In the NC group and T2DM group were not found in serum leptin levels and BMD values and various parts of the OP association. Conclusion: ① NC serum leptin levels and TC, HDL-C into a [positive correlation; T2DM serum leptin levels and BMI, WC, 120minc-peptide levels were [positively correlated with height, E2 levels were negatively correlated. ② NC and T2DM group BMI, WC and WHR were significantly associated with BMD [positively correlated. NC group BMD values and TC, HDL-C was negatively correlated. BMD in various parts of the T2DM group was negatively correlated with BP, right forearm BMD values were negatively correlated with FPG. In T2DM group was not observed BMD values associated with lipid. ④ T2DM group, NC group and the two groups after the merger was not discovered leptin levels associated with BMD and OP. Objective: To analyze the Yunnan region population characteristics LEPR gene polymorphisms Gln223Arg explore LEPRGln223Arg polymorphism and bone mineral density in patients with T2DM Yunnan region and the relevance of osteoporosis. Methods: 239 patients with type 2 diabetes mellitus (T2DM group), 287 healthy controls (NC group). Genomic DNA tests LEPR Gln223Arg polymorphism. Results: ① 526 subjects, Yunnan region in LEPR genotype AA, AG and GG frequencies were 2.8%, 21.7% and 75.5%, allele frequency distribution of G and A, respectively, 83.2% and 16.8%. ② T2DM group and NC group AA, AG, GG genotype group differences were not associated with the occurrence of the OP. ③ T2DM group LEPR gene Gln223Arg the GG genotype group L4 and total body BMD values were greater than AG and AA genotype, AG genotype group L4 and total body BMD values greater than AA genotype group, there was a significant difference (P lt ; 0.05). NC group LEPR gene Gln223Arg the GG genotype group L1-4 and systemic BMD values are greater than AG and AA genotype, AG genotype group L4 BMD values greater than AA genotype group, but no significant difference. ④ NC group Gln223Arg LEPR gene polymorphism and serum leptin levels there was a significant correlation between (R = 0.361, P = 0.021). But in T2DM found no correlation between leptin levels with. Conclusion: ① LEPR gene polymorphisms with T2DM group G1n223Arg systemic and L4 BMD in association with the NC group L1-L4BMD related carrying GG genotype had higher BMD values, suggesting that G allele bone mass in patients with diabetes protection factor.
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