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[Objectives]①To investigate the changes of serum interleukin -6(IL-6) fractalkine(FKN or CX3CL1) levels in chronic obstructive pulmonary disease(COPD) with acute exacerbation of mild、moderate and severe group of patients,explore the relationship between levels of cytokines IL-6、FKN and disease progression in COPD②By measuring the patient’s lung function of patients, explore the relationship between levels of serum IL-6、FKN and the level of lung function.[Methods] Selected the 79 patients hospitalized in the respiratory department of patients were diagnosed with COPD, and acute exacerbation of.Excludeed confounding factors, lined after the pulmonary function tests forced expiratory volume in one second% predicted (FEV1%Pre) were divided into mild、moderate and severe groups,28 patients with mild,28 patients with moderate,23 patients with severe. And extracted the second day of fasting morning blood of patients, masured serum levels of IL-6 and FKN.[Results]①Acute exacerbation of COPD mild、moderate and severe group of patients serum IL-6、FKN levels, by statistical analysis,P<0.01, there were significant differences, three groups of patients in the serum IL-6 FKN unequal level;②Comparison between two lines, three groups of patients the level of IL-6 is not the same, and severe patients the highest levels of IL-6, patients with moderate levels of IL-6 in the second highest, patients with mild levels of IL-6 minimum, The comparison between groups.P values were less than 0.05; when compared between mild and moderate group of FKN, P<0.05, statistically significant differences,higher than the mild to moderate. when compared between mild group and severe group, the P<0.05, statistically significant differences, higher than the mild to severe, when compared between moderate group and severe group P>0.05, the difference was not statistically significant;③Serum IL-6、FKN of patients correlation with pulmonary function (forced expiratory volume in one second%predicted)findings:FEV1% predicted decrease with the levels of IL-6 increase,P=0.000,r=-0.877, that IL-6 and FEV1% predicted a negative correlation; FEV1% predicted decrease with the level of FKN increase,P=0.000,r=-0.548, that FKN and FEV1% predicted negative correlation exists.[Conclusions]1.Measured of COPD patients levels of serum cycokines, contribute to the further study of cytokines in the pathogenesis of the role of COPD.2. COPD with acute exacerbation of mild, moderate and severe group of patients the difference in serum IL-6 expression,IL-6 levels and FEV1% predicted correlation may indicate:More severe disease, IL-6 levels higher, the more severe inflammatory response,lower lung function in patients.3.COPD with acute exacerbation of mild, moderate and severe groups of different serum FKN expression,FKN levels and FEV1% predicted correlation may indicate: FKN and the development of COPD may have some relationship, with the increase of FKN, a downward trend in pulmonary function, however, in moderate to severe patients no significant differences in FKN, may indicate:when developed to a certain degree of COPD (moderate and severe) after, FKN expression was not much change, and patients may develop more serious diseases,such as:pulmonary hypertension, pulmonary heart disease and so on.
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