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Pupa Oil Properties and purification of α- linolenic acid

Author: XuJin
Tutor: LiJing
School: Southwestern University
Course: Microbial and Biochemical Pharmacy
Keywords: α- linolenic acid Rancidity Purification Urea inclusion Saponification acidolysis
CLC: R284.1
Type: Master's thesis
Year: 2011
Downloads: 128
Quote: 2
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Abstract


Insects Lepidoptera Saturniidae silkworm silkworm (Bombyx moil L) after the pupa cocoon is an important byproduct of the silk industry , China's annual output of 120,000 tons dry chrysalis above . Pupa with lowering blood pressure , blood pressure, improve immunity, enhance intelligence and vision , cancer and other pharmacological functions. This paper focuses on the separation of silkworm chrysalis oil extraction and fatty acid composition, the basic nature and effect of silkworm chrysalis oil fat rancidity factor , pupa oil a-linolenic acid (a-linolenic acid) separation and purification conduct a study to develop the depth of silkworm chrysalis oil provide a theoretical basis . The main results are as follows : 1. Were Soxhlet extraction and supercritical CO2 Fluid Extraction pupa oil, Soxhlet extraction the optimum conditions were: 30 ℃ ~ 60 ℃ petroleum ether as solvent extraction is better . Extraction time 7h, extraction rate of 28.53% . Supercritical CO2 Fluid Extraction optimum extraction conditions : extraction pressure of 30MPa, extraction temperature 45 ° C, extraction time of 3 hours , pupa oil extraction rate of 28.37% . 2 pupa storage temperature is higher, the longer , the more serious the pupa oleic defeat ; pupa optimum humidity storage conditions 70% ~ 80% RH, reeling and post-processing technology on the quality of silkworm chrysalis oil plays a key role , poor pupa the pupa oil quality the worst period in the summer heat , drying time can prevent pupa oleic defeat . 3 . The pupa oil saponification hydrolysis , optimum conditions : water bath temperature 70 ℃, time 70min, NaOH concentration of 4% , this condition mixed fatty acids obtained after hydrolysis of acid value 161.24mgKOH / g. By gas - mass spectrometry analysis, silkworm chrysalis oil, a-linolenic acid content of about 30.45% , oleic acid (Oleic acid) 25.77%, palmitic acid (Palmitic acid) 22.82%, linoleic acid (Linoleic acid) 7.52%. 4 acetone crystallization temperature optimum conditions : mixed fatty acid and acetone mixed at the ratio of 1:6 , -30 ℃ cold 5h, ie, with a purity of 65.94% of a- linolenic acid. . Urea adduction optimum conditions : Fatty Acids: Urea: methanol = 1:3:8 , bath 30min, -5 ℃ inclusion 16 hours , to obtain a-linolenic acid purity of 74.26% .

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Traditional Chinese medicine chemical > Chemical analysis and identification
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