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Inclusion compound ampelopsin its antioxidant activity

Author: WangLiPing
Tutor: WangWei
School: Shaanxi Normal University
Course: Organic Chemistry
Keywords: Flavonoids Ampelopsin Inclusion Complex Hydroxypropyl-β- cyclodextrin Antioxidant activity
CLC: TQ914.1
Type: Master's thesis
Year: 2011
Downloads: 32
Quote: 0
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Abstract

Flavonoids are an important class of natural organic compounds produced in the plant metabolic processes, their physiological activity is very broad, universal attention by researchers in recent years. The ampelopsin are flavonoids, it also has a high biological activity, often used as a food preservative and antioxidant. The current research is mainly focused on the pharmacological aspects of the function and make the best use can be achieved in order to truly matter, further systematic study its stability under different conditions, its application is very necessary. The main work of this paper consists of four parts: the first chapter: First, the details of the structure and classification of flavonoids. Second, more comprehensive introduction to the nature of ampelopsin pharmacological activity, as well as the current status quo. Chapter II: The inclusion complex solution mixing method and grinding method prepared by two methods, and β-cyclodextrin (β-CD) ampelopsin inclusion of different proportions by infrared spectroscopy method (IR) , the powder X-ray diffraction law (XRD), ultraviolet spectroscopy (UV), and environmental scanning electron microscopy (SEM) the inclusion complex of the qualitative and quantitative analysis, and determine the cooperation with the package has occurred. On this basis, the clathrate ampelopsin the content and its apparent stability constants were determined using UV spectroscopy and quantitative phase solubility. Experimental results show that, the grinding method clathrate ampelopsin content is better than the solution mixing method, various the clathrate type are AL-type, and feeding the best ratio of 1:1 inclusion. Chapter III: The grinding method were prepared 6 different degree of substitution (DS), hydroxypropyl-of β-cyclodextrin (HP-β-CD) inclusion complexes with ampelopsin by infrared spectroscopy (IR ), X-ray diffraction law (XRD), ultraviolet spectrum, France (UV), the environmental scanning electron microscope (SEM) on the six kinds of clathrate phase identification was determined by the phase-solubility method HP-6 kinds of different degree of substitution β-CD ampelopsin inclusion apparent stability constant (Kc). Experimental results show that, of 6 different degree of substitution of the HP-β-CD clathrate ampelopsin with HP-β-CD molar ratio of as 1:1 inclusion type are the AL type; When the DS = 6.8 When, HP-β-CD / the content ampelopsin snake grape prime clathrate. Chapter IV: acetic acid medium, the Fenton system generates hydroxyl radicals rapidly with Amaranth role, it faded, the formation of hydroxyl radicals in the absorbance of 292 nm was measured at system changes can be determined indirectly. Measurement conditions, to determine the best experimental conditions of the system. Antioxidant activity of hydroxyl radical scavenging obvious dose-effect relationship, the experimental determination of the inclusion complex of several flavonoid substances to remove the ability of the hydroxyl radical, its ability to order from strong to weak: ampelopsin clathrate gt; orange peel pigment clathrate gt; the the baicalein clathrate gt; New flavonoids inclusion gt; ipriflavone clathrate the gt; the thorn Formononetin clathrate. Chapter 5: the ampelopsin clathrate stability under the influence of different pH, temperature and metal ions. The experimental results show: ampelopsin clathrate in the aqueous phase becomes unstable with time and temperature changes. The pH value also affects the clathrate stability of ampelopsin important factor in acidic and neutral conditions, ampelopsin clathrate showed better stability. Metal ions Na, Mg2, Zn2 and Ca2 on the the inclusion complexes ampelopsin stability within 6h had no significant impact, but A] 3 and Cu2 ion ampelopsin clathrate significant, should avoid contact with the application.

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