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In Vivo Degradation Study of β-Tricalcium Phosphate/Poly-L-Lactide Composites in Cancellous Bone

Author: WangXiao
Tutor: LiuYuJie
School: PLA Postgraduate Medical School
Course: Surgery
Keywords: β- tricalcium phosphate / poly-L- lactic acid Poly-L- lactic acid Bioabsorbable material In vivo degradation Osteoinductive
CLC: R318.08
Type: Master's thesis
Year: 2011
Downloads: 10
Quote: 0
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Abstract


Objective: comparative study of beta - tricalcium phosphate / poly - L - lactic acid (β-TCP/PLLA) composites and poly - L - lactic acid (PLLA) cancellous bone degradation characteristics . Method : will β-TCP/PLLA the composites and PLLA material were implanted in 12 New Zealand white rabbits were bilateral femoral condyle and lateral condyle , while its hind limbs subcutaneous and muscle pouches each implantation of a β -TCP / PLLA The composite material block . 3 , 6, 12, and 24 weeks after the time point drawn each time point 4 . Each time point was measured the biological absorption rate , using scanning electron microscopy and optical microscopy to observe the morphological changes within the cancellous bone around the new bone creeping substitution , foreign body reaction , and liver and kidney histopathological changes . Results: various the time point β-TCP/PLLA surrounding bone to fit closer than PLLA material , no obvious foreign body reaction . 6 Zhou Shisheng matter of the β-TCP/PLLA material absorption rate of less than PLLA material , 12 weeks after the physical absorption rate of growth accelerated , while the surface of the material is uniformly distributed pores and fissures , no abnormal liver and kidney slices ; 24 weeks after surgery within two materials showed no new bone creeping substitution . Conclusion : β-TCP/PLLA biocompatibility of composite the early degradation than PLLA material slow conducive to strong fixation of the graft implantation early ; accelerate the degradation after six weeks , 24 weeks, no osteoinductive phenomenon .

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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