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The Expression of CLIC1 and LyGDI in the Colorectal Cancer and Their Clinical Significance

Author: YangXiaoSong
Tutor: ChiPan
School: Fujian Medical
Course: Surgery
Keywords: Colorectal Cancer CLIC1 LyGDI Immunohistochemistry Tissue microarray Survival analysis
CLC: R735.34
Type: Master's thesis
Year: 2011
Downloads: 45
Quote: 0
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Abstract


Objective: Colorectal cancer is a common malignancy, morbidity and mortality in developed countries are ranked third. In recent years, the incidence of colorectal cancer rate is getting higher and higher. Most patients had advanced stage colorectal cancer early lack of obvious symptoms, there are obvious symptoms, so the prognosis is poor. The complex pathogenesis of colorectal cancer, a variety of studies have shown that there are a variety of oncogene activation and inactivation of tumor suppressor genes in normal colorectal mucosa during carcinogenesis. Find colorectal cancer occurrence and development of tumor markers can assist in the early detection of colorectal cancer, thereby enhancing the surgical treatment to reduce the morbidity and mortality of colorectal cancer. In this study, the main Research of CLIC1 \u0026 LyGDI organizations, next to the colorectal junction rectal adenomas and colorectal cancer tissue differences in expression levels, and the difference of the CLIC1, and LyGDI protein level in patients with colorectal cancer, the clinicopathological factors and survival rate relationship. Method: 1. Organize and colorectal cancer tissues the Western blot technique the detection LyGDI in the colorectal cancer next expression. And compare LyGDI organization next in colorectal cancer and differential expression in colorectal cancer tissues. Construction of tissue microarray by immunohistochemistry tissue microarray technology to detect the of CLIC1 and LyGDI next to the 150 cases of colorectal mucosa organization, differential expression in 52 cases of colorectal adenoma and 187 cases of colorectal cancer tissues. And analyze the relationship between the clinical pathology and prognosis of survival in patients with of CLIC1 and LyGDI expression levels in colorectal cancer and colorectal. Results: 1. Discovered by western blot technology: LyGDI expression levels in colorectal cancer was significantly higher than in the colorectal mucosa adjacent tissue expression levels, a statistically significant difference. 2 by immunohistochemistry tissue microarray technology found the CLIC1 colorectal next organization, in turn gradually elevated expression levels in colorectal adenoma and colorectal cancer tissues, a statistically significant difference. CLIC1 expression levels and colorectal cancer staging, staging the higher the higher the level of expression of CLIC1, the of CLIC1 expression level and the prognosis of patients survive CLIC1 positive expression group survival rate was significantly lower than the expression of CLIC1 negative in group , the difference was statistically significant. CLIC1 expression level in colorectal cancer tissues and patient age, gender, tumor size, differentiation and parts no significant relationship. The knot found the LyGDI expression levels in colorectal cancer by immunohistochemistry tissue microarray technology than rectal cancer tissues and adenoma and elevated expression, a statistically significant difference. LyGDI the expression levels and the differentiation of the tumor, the level of differentiation of colorectal lower the higher the expression level of LyGDI; LyGDI the expression levels and colorectal cancer staging, staging the higher, LyGDI the expression level of the higher . Colorectal cancer tissues the LyGDI expression levels and patient age, gender, tumor size and location was no significant relationship. LyGDI expression level and the prognosis of patients survive no significant relationship. Survival rate no significant difference in survival rate LyGDI positive expression group and LyGDI negative expression. Conclusion: CLIC1 with the progression and prognosis of colorectal cancer related, LyGDI the development of colorectal cancer, and prognosis. The CLIC1 \u0026 LyGDI two tumor markers in colorectal cancer potential.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Colorectal tumors
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