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Mesoporous silica nano-particles (MSN) its nanoscale size, high specific surface area, controlled pore structure rules, the surface can be modified, good biocompatibility, in the field of bio-medicine, especially drug carrier tape shows a broad application prospects. Currently, MSN as a pharmaceutical carrier tape system focused on the development of the carrier of the \select, set out with the media and the regulation of the conditions of the carrier tape only sporadic research, the lack of a complete theory. In addition, the study set out with the drug concentration of several commonly used probe drugs, such as ibuprofen, doxorubicin, and set out with some other drugs to the lack of an ideal carrier is relatively small. Above Research via MSN to several drugs carrier tape with the release of the study, the first time MSN NAD, RAPA DOX with RAPA contained a total of; and more in-depth study of the drug carrier tape and release process interaction force between the carrier, drugs, as well as media relations, the carrier tape and release mechanism analysis and summary. In this paper, the surface modification of MSN, the impact the adsorption media choice, factors such as pH of the medium of DOX carrier tape, MSN set out with a higher amount of DOX loading amount of up to 250mg / g higher than generally reported in drug loading; adsorption model fitting analysis MSN DOX carrier tape mechanism. In this paper, the complexation of metal cations, for the first time MSN to proton coenzyme NAD carrier tape, ideal conditions for download with the amount of up to 440mg / g. At the same time, by studying the carrier tape media metal cation loading amount of NAD and pH-responsive release behavior, a more in-depth analysis of the system based on the metal cation coordination role of drug-loaded carrier tape and release mechanism. Firstly using MSN successful carrier tape superhydrophobic antiinflammatory drug rapamycin (RAPA) through the tape carrier medium selected electrode and found that The RAPA carrier tape large amount of carbon tetrachloride as a tape carrier medium , up to 124mg / g. At the same time, the study of the solubility parameter of the carrier tape media interaction force between RAPA molecules with the media, as well as drug loading. In addition, the study of the in vitro release of the tape carrier system has good sustained release effect. This article is the first time the use of the synergistic effect of the drug, MSN achieve the hydrophilic drugs DOX and hydrophobic drugs RAPA total contained. Research the RAPA upload with amount of DOX loading amount of dependencies to achieve two drugs are set out with the amount of adjustment; study contained a total system DOX release behavior. That contained a total system in certain drug concentration, relative to DOX as well as the RAPA single-board systems, kill lung cancer cell line A549.
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