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Preparation and Characterization of Drug Loaded Polymeric Microcapsules

Author: LiuLiNa
Tutor: KongXiangZheng
School: Jinan University
Course: Polymer Chemistry and Physics
Keywords: Microcapsules Complex coacervation Coated Insect hormones Controlled release
CLC: TQ460.1
Type: Master's thesis
Year: 2010
Downloads: 67
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Abstract


The whey protein (WP) / gum arabic (AG) and gelatin (GE) / AG as wall material, insect hormone component oil acetate (OA) and dodecanol acetate (DA) coated microcapsules obtained were characterized on the release behavior of the drug in the microcapsules were investigated. Depending on the wall material and core material combination, can be divided into three parts: (1) WP / AG complex coagulation cover OA; (2) WP / the AG complex coacervation coated DA; (3) GE / AG complex coacervation coated with OA. (1) WP / AG complex coagulation cover OA. Oleyl alcohol with acetic anhydride in a molar ratio of 1/1.7, and oleyl alcohol with acetic anhydride 0.2 wt% of the total mass of the catalyst on the amount of p-toluenesulfonic acid, 25? C for 3 h synthesized OA insect hormone one of the components, and with infrared spectroscopy, nuclear magnetic resonance spectrometer characterized it. Using a complex coacervation method WP / AG as wall material for the synthesis of OA were coated with different wall material and the total concentration of oil containing microcapsules were prepared using a gas chromatograph of the fuel load and the covering rate of the microcapsules determination. The experimental results show that with the increase of the total concentration of the wall material, the core material OA coated rate first increased and then decreased trend. When the total concentration of the wall material is 0.5 wt%, the fastest release rate of the core material. Found carrier OA prepared size of the microcapsules in the 5 to 8 μm, and OA to the form of the core-shell structure is coated on the inside the wall material of the microcapsules was observed by scanning electron microscopy (SEM). (2) WP / AG complex coagulation cover DA. Dodecyl alcohol and acetic acid in a molar ratio of 1/1.2, the catalyst p-toluenesulfonic acid dosage is dodecyl alcohol and acetic acid in the total amount of 1.0 wt%, the amount of toluene portability alkyd total amount of 45 wt%, 120? C heated to reflux for 3 h synthesis of insect sex hormone component of the DA, and as a core material prepared carrier DA microcapsules, the core wall ratio, the total concentration of the wall material, crosslinking agent and other factors affect the coating examined. Experimental results show that the ratio increases, the total concentration of the same wall material with the core wall, increased drug loading of the microcapsules, the release rate of the core material up; same core wall ratio, 1.0% of the total concentration of the wall material of the micro-capsules release In fastest; added of the crosslinking agent to improve the covering rate of the core material DA, slowing the rate of release of the core material. WP / AG coated OA system, on the curve overall is released showing two paragraphs constant rate trends, early rapid release and slow release late. And the system covering rate of DA decreased slightly, but significantly accelerated release rate. (3) GE / AG complex coagulation cover OA. GE / AG as wall material coated synthetic OA. The effects of the amount of crosslinking agent, the the different core wall ratio, when the total concentration of the different wall material coated situation. Microcapsules were characterized its release behavior were investigated. The experimental results show that the crosslinking agent added can get higher fuel load. With the increase of the amount of crosslinking agent, the fuel load of the microcapsules, the covering rate increases the release rate of the core material decreases. WP / AG system compared with the increase of the total concentration of the wall material, the fuel load and the coating rate increased, the release rate is accelerated. SEM observation of the obtained microcapsules, we believe that the carrier DA microcapsules form a core-shell structure.

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