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~ (11) C-PD153035 PET / CT detection of EGFR expression in the guidance of the diagnosis of lung cancer and chemoradiotherapy

Author: ZhaoFen
Tutor: YangGuoRen；YuanShuangHu
School: Jinan University
Course: Medical Imaging and Nuclear Medicine
Keywords: Epidermal growth factor Cancer , non- small cell lung Concurrent chemoradiotherapy Tomography , positron emission type Quinazoline
CLC: R734.2
Type: Master's thesis
Year: 2011
Downloads: 27
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Abstract

Objective: To detect non-small cell lung cancer (non small cell lung cancer, NSCLC) before and after radiotherapy in patients with the serum free epidermal growth factor receptor (sEGFR) concentration, and with the primary tumor ^{11 C-PD153035 PET / CT uptake values ??compare to investigate the correlation between the two. Methods: From July 2009 - March 2010, 15 patients (the men ^{11 cases, female four cases; 48-78 years old) confirmed by pathology underwent three-dimensional conformal radiation therapy (Conformal radiation therapy, CRT) of patients with NSCLC (adenocarcinoma five cases, one cases of large cell lung cancer, squamous cell carcinoma 9 cases) one week before radiotherapy and radiotherapy after the week line ^{2 11 C-PD153035 PET / CT imaging and inspection before fasting blood 4ml measurement before treatment, after the lesion maximum standardized uptake value (maximum standard uptake value, SUVmax) and calculated before and after treatment SUVmax of the change ΔSUVmax and the percent change in SUVmax ΔSUVmax%; Elisa assay The serum sEGFR concentration Cb and calculate the percentage change value ΔCb and changes before and after radiotherapy ΔCb. The correlation analysis of various indicators and the two measurement methods. Results: 15 patients before treatment ^{11 C-PD153035 PET / CT imaging and collected fasting venous blood, completed according to plan treatment underwent enhanced CT scan of the chest, including 10 patients at the end of treatment two weeks second ^{11 C-PD153035 PET / CT and fasting blood collection. Before and after treatment SUVmax were 3.28 ± 1.20 and 2.45 ± 1.44, ΔSUVmax ΔSUVmax% were 0.884 ± 0.653 and 29.76% ± 17.32%; before and after treatment sEGFR concentration Cb were 0.886 ± 0.207μg / l, 0.818 ± 0.239μg / l the ΔCb and ΔCb% 0.134 ± 0.085μg / l and 14.81% ± 10.28%; were before treatment, the percentage change in after sEGFR of SUVmax and serum concentrations of Cd and both showed significant positive correlation ρ values ??were 0.737,0.872 and 0.648 , p less than 0.05; Conclusion: before and after radiotherapy in patients with advanced NSCLC serum sEGFR concentration ^{11 C-PD153035 PET / CT uptake values ??have a good correlation between joint application, expected for clinical screening NSCLC patients with high EGFR expression more positive treatment provides an effective means. The second part ^{11 C-PD153035 PET / CT imaging in detecting EGFR expression with locally advanced NSCLC put the purpose of the preliminary study of the relationship of chemotherapy: the through ^{11 C-PD153035 [^{11 C-4-(3 - bromophenyl amino) -6, the seven pairs methoxy quinoline the oxazoline ^{11 C-4 - (3-bromoanilino)-6 ,7-dimethoxyquinazoline ] positron emission tomography / computed tomography (positron emission tomography / computed tomography, PET / CT) imaging to detect patients with advanced NSCLC put the tumor EGFR (epidermal growth factor receptor, EGFR) expression before and after chemotherapy level, to explore its relationship with the short-term effect of the comprehensive treatment of NSCLC patients put. Methods: From July 2009 - March 2010, 15 (the men ^{11 cases, female four cases; 48-78 years old) patients with pathologically confirmed underwent three-dimensional conformal radiation therapy (conformal radiation therapy, CRT) and concurrent chemotherapy patients with NSCLC (adenocarcinoma five cases, one cases of large cell lung cancer, squamous cell carcinoma 9 cases), respectively, one week before radiotherapy and after radiotherapy 4 weeks ^{11 C-PD153035 PET-CT imaging, measurement before treatment, after the lesion maximum standardized uptake value (maximum standard uptake value SUVmax) and calculate the percentage changes before and after treatment the SUVmax of the change ΔSUVmax and SUVmax ΔSUVmax%; comparative analysis of treatment response group and reaction group of patients with SUVmax and its changes, independent sample t-test inspection differences. Results: 15 patients were carried out before treatment ^{11 C-PD153035 PET / CT imaging, treatment for 4 weeks after enhanced chest CT scan completed as planned, of which 10 patients four weeks after the end of treatment times ^{11 C-PD153035 PET / CT. Before and after treatment SUVmax were 3.28 ± 1.20 and 2.45 ± 1.44, the difference was not statistically significant (t = 0.13 P gt; 0.05); the reaction group patients with treatment before SUVmax of 2.69 ± 0.73, significantly lower than the non-response group 4.17 ± 1.26 (t = -2.89, P lt; 0.05), but no significant difference before and after treatment SUVmax changes (t = -1.19, P gt; 0.05), and the two groups of patients ΔSUVmax% difference was not statistically significant (t = -0.007, P gt; 0.05). Draw the ROC curve and find the best SUVmax values ??to determine the efficacy of treatment before the SUVmax = 2.66 when treatment response prediction sensitivity, specificity, positive predictive value, negative predictive value was 66.67% (4/6), 100% (9/9), 100% (4/4), 81.8% (9 / ^{11 ). Conclusion: Treatment ^{11 C-PD153035 PET / CT imaging radiochemical comprehensive treatment efficacy can predict a certain extent in order to filter out to take a more proactive treatment of patients at high risk of treatment resist expected improve the therapeutic effect.}}}}}}}}}}}}}}}}

~ (11) C-PD153035 PET / CT detection of EGFR expression in the guidance of the diagnosis of lung cancer and chemoradiotherapy

Abstract

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