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Study on Serum Visfatin Level in Coronary Heart Disease Combined Type 2 Diabetes Patients Mellitus and Statins Intervention

Author: CuiQingRi
Tutor: ZhangHui
School: Hebei Medical University
Course: Internal Medicine
Keywords: Coronary heart disease with type 2 diabetes Visfatin High - sensitivity C - reactive protein
CLC: R541.4
Type: Master's thesis
Year: 2011
Downloads: 52
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Abstract


Purpose: the common diseases of coronary heart disease is a serious hazard to human health, symptoms or disability, death occurred in the 40-year-old male with early onset in women. Coronary heart disease the most important pathological changes of atherosclerosis, the result of a complex interaction of many factors, inflammation plays an important role in coronary atherosclerosis occurred in the development process, from coronary plaque the formation and progress of both to vulnerable plaque rupture of inflammatory mediators involved. Diabetes is an important risk factor for cardiovascular disease, and mortality in patients with coronary heart disease diabetes doubled. The study showed that: visfatin adipocytokines associated with vulnerable plaque angiogenesis, endothelial function, inflammation, and broad participation in the process of atherosclerosis. High-sensitivity C-reactive protein (high sensitivity C-reactive protein, hs-CRP) rapidly increased in the acute phase of inflammation, is a sensitive and reliable marker of inflammation. Studies show a significant correlation between serum visfatin and hs-CRP. Statins lower blood cholesterol levels by blocking the synthesis of cholesterol in the body, as well as antioxidant protection of vascular endothelial function, anti-inflammatory role. The experiment studies the dynamic changes of coronary heart disease diabetes patients serum visfatin levels and hs-CRP levels and the correlation between; explore visfatin role in the development of coronary heart disease with diabetes, as a new biological indicators to assess the severity of the disease and infer prognosis. Methods: diagnostic criteria for coronary heart disease: coronary angiography using internationally accepted diameter method assessing coronary artery stenosis, where stenosis ≥ 50% were defined as CHD, lt; 50% were defined as NCHD; diagnostic criteria for diabetes using 1999 the WHO criteria: diabetes symptoms any time the level of plasma glucose ≧ 11.1mmol / l (200mg/dl) ≧ 7.0mmol / l (126mg/dl) or fasting plasma glucose (FPG) or the oral glucose tolerance test (OGTT) postprandial 2h glucose (2hPG) ≧ 11.1mmol / l (200mg/dl). Select patients with type 2 diabetes diagnosis of coronary heart disease hospitalized in the Department of Cardiology of our hospital from June 2009 to June 2010, 30 patients, 16 males and 14 females, aged 49 to 68 years, mean age (58.3 ± 8.7) years, Height (165.4 ± 5.3) cm, weight (62.1 ± 4.6) kg. 30 healthy patients of the same period, from healthy subjects of the examination center of our hospital, in which 17 male patients, 13 females, aged 48 to 67 years, the average age (54.6 ± 12.3) years, height (162.4 ± 7.5) cm weight (63.2 ± 6.1) kg, were excluded coronary heart disease and type 2 diabetes and hyperlipidemia oral glucose tolerance test to exclude. All subjects except: stroke, lung function insufficiency, renal insufficiency, hepatic dysfunction, cancer, blood diseases, recent hormone use, clear valvular heart disease, and the merger of patients with serious diseases. Each subject was no significant difference in age, gender. Healthy controls take overnight fasting blood, coronary heart disease in patients with diabetes take overnight fasting blood time and and atorvastatin to Ting calcium intervention 14 days after overnight fasting venous again. Comparing two groups of lipids, Hs-CRP, serum visfatin levels compare drug intervention drug intervention before and after coronary heart disease and diabetes serum visfatin levels and Hs-CRP level between correlation. Results: healthy average age of the control group (54.6 ± 12.3) years old, the average age of coronary heart disease diabetes group (58.3 ± 8.7) years old, the two groups compared to the average age, gender composition of the healthy control group, no significant difference (P> 0.05); TC (4.26 ± 0.73) mmol / L, LDL-C (2.71 ± 0. 34) mmol / L, TG (1.20 ± 0.35) mmol / L, HDL-C (1.05 ± 0.21) mmol / L, hs-CRP ( 3.95 ± 1.21) mg / L, Visfatin (2.28 ± 0.57) ng / mL, coronary heart disease with diabetes group TC (5.42 ± 1.63) mmol / L, LDL-C (3.06 ± 0.42) mmol / L, TG (1.45 ± 0.37 admission) mmol / L, HDL-C (1.17 ± 0.26) mmol / L, hs-CRP (20.1 ± 5.02) mg / L, Visfatin (7.13 ± 1.02) ng / mL, the healthy control group with coronary heart disease with diabetic patients The pre-treatment of TC, LDL-C, TG, HDL-C, hs-CRP, Visfatin mean of two samples were statistically significant difference (P <0.05). Coronary heart disease patients with diabetes mellitus before and after treatment, after treatment, the TC (4.39 ± 0.63) mmol / L, LDL-C (2.45 ± 0.54) mmol / L, TG (1.32 ± 0.29) mmol / L, and HDL-C (1.24 ± 0.21 ) mmol / L, hs-CRP (9.07 ± 2.43) mg / L, Visfatin (4.35 ± 0.67) ng / mL values ??decreased significantly, paired t-test, P <0.01, the difference was statistically significant; hs-before and after treatment CRP and Visfatin was a positive linear relationship, r values ??were 0.467,0.572. Conclusion: before the intervention of a coronary heart disease patients with diabetes mellitus drug serum visfatin, hs-CRP levels higher than the healthy control group, suggesting that serum visfatin, hs-CRP participation in the development of the disease. 2 drug intervention, in patients with coronary heart disease with diabetes mellitus and hyperlipidemia lipids, serum visfatin, hs-CRP levels decreased, suggesting that statins also play an anti-inflammatory effect in the lipid-lowering while. 3 serum visfatin, hs-CRP levels of correlation between serum visfatin predictor of a new assessment of disease progression and prognosis.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Coronary arteries ( atherosclerosis ),heart disease (CHD)
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