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The purpose of this project on the basis of a review of Chinese and Western ancient and modern literature, reference Yiqihuoxue piece earlier gains in two aspects observe the Yiqihuoxue square hypertensive stroke before state neuroprotective effects from clinical and animal experiments. In this study, a randomized controlled clinical trials and animal experiments, explore of Yiqi Huoxue on hypertensive stroke before state neuroprotective effect the validity and the possible mechanism of action. Method 1. Clinical research component: Choose met the inclusion criteria hypertensive stroke before the status of 57 patients, remove the loss, and lost to follow-cases, more than a simple randomized into the treatment group, 28 patients and the control group 27 cases, two groups based therapies same treatment group treatment of Yiqihuoxue square. Before treatment, after treatment, according OUTCOME MEASURES clinical observation. Animal experiments: yellow, such as training and other reports of renal double clamp method to copy a rat model of renal vascular hypertension, hypertension model in line with the experimental requirements were randomly divided into a treatment group, 17 cases and 16 cases, 15 cases of the control group and blank group gavage treatment group piece of Yiqihuoxue, control group fed with thanks to the activities of the rats the Aspirin blank group fed with distilled water, the treatment process, after the end of treatment with pathological examination of brain tissue ultrastructure observation serum biochemical indicators to evaluate its efficacy. After the test, the establishment of a database using SPSS13.0 statistical software for statistical analysis, the final results of the the clear treatment group and the control group. Results 1 clinical studies: statistical analysis, the two groups before treatment, general information including gender, age, and other pre-treatment baseline induced comparable. Statistics show clinical symptoms to improve the situation, biochemical, arterial blood flow velocity, the difference was statistically significant (P lt; 0.05). Animal experiments: statistical analysis, statistically significant (P lt; 0.05) compared with SD rats model of hypertension treatment group, blood pressure, biochemical indicators CPR. Ultrastructural observation of brain tissue: the treatment group compared with the control group of rats with nerve cell damage reduced blood vessel wall is not obvious thickening. Conclusion 1. Yiqihuoxue only alleviate hypertensive patients with stroke before neurological deficit, improve the patient's clinical symptoms of the hypertensive stroke before the state has a certain neuroprotective effect have a preventive effect on the incidence of stroke . 2 Yiqihuoxue films can promote hypertension model SD rats recovery of neurological function, reduce nerve damage, reduce the inflammatory response of rat nerve cells, to relieve brain tissue edema, have certain neuroprotective effect.
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