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Diagnosis and Trentment for Food Allergy

Author: ZuoJunMei
Tutor: HuYan
School: Chongqing Medical University
Course: Pediatrics
Keywords: Skin prick test The rash group average diameter Open food challenge Diagnostic value The rash Mission longest diameter Skin Index Milk protein allergy Free amino acid formula Depth hydrolyzed formula Soy formula
CLC: R725.9
Type: Master's thesis
Year: 2011
Downloads: 67
Quote: 0
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Abstract

By skin prick test a rash group average diameter of open food challenge test correlation, have confirmed the value of food allergies, skin prick tests rash Mission critical value point, provide the basis for simplified clinical diagnostic procedures. Methods Chongqing Medical University Children's Hospital child protection suspected food allergy 173 children underwent skin prick test and open food challenge test. Measure and record the average diameter of the skin prick tests rash group, through the open foods excitation test diagnosed children with food allergies. Analysis of skin the prick tests rash group average diameter of the sensitivity, specificity, positive predictive value, negative predictive value; using SPSS13.0 software package the average diameter of the area under the curve of receiver operating characteristic curve evaluation of skin prick tests rash group The diagnostic value of food allergies, and diagnostic cutoff for 100% of the average diameter of the rash group. Results 173 cases of infants were 283 food challenge test, positive results 129 times. 99 cases of infants and young children are diagnosed with food allergies. The area under the curve of the receiver operating characteristic curve of the protein, egg yolks, milk skin prick test were 0.794,0.804,0.904. When the average diameter of skin prick tests rash group ≥ 8.5mm, 5.5mm, 5.5mm when the skin prick test protein, egg yolk, milk allergy diagnostic accuracy rate of up to 100%. Conclusion skin prick tests rash group average diameter of the eggs, the better, can avoid some of the suspected food allergies in children food challenge test by 100% diagnostic cutoff for the accuracy of the clinical diagnosis of milk allergy. Section II skin prick test different methods of measurement by the average diameter of the skin prick test rashes group of infants eggs, milk allergy diagnostic value evaluation purposes, the longest diameter, skin index with open food challenge test correlation obtained have confirmed the value of food allergies, skin prick tests rash Mission critical value points, and compare the diagnostic accuracy of different measurement methods, to provide a basis for simplified clinical diagnostic procedures. Methods Chongqing Medical University Children's Hospital child protection suspected food allergy 173 children underwent skin prick test and open food challenge test. Measure and record the average diameter of the skin prick tests rash group, the longest diameter, skin index; through the open foods excitation test diagnosed children with food allergies. Analysis of the sensitivity of the different methods of measurement of skin prick tests rash group using SPSS13.0 software package, specificity, positive predictive value, negative predictive value. The area under the curve of the receiver operating characteristic curve comparing skin prick test the diagnostic value of the different methods of measurement of food allergies. Results when the average diameter of the skin prick tests rash group reaches or exceeds a certain critical value (protein 8.5mm; yolk 5.5mm; milk 5.5mm), food allergy diagnostic accuracy rate of up to 100%; longest diameter and skin rash Mission The index corresponding diagnostic cutoff for were: 14.0mm/2.67; 6.0mm/1.67; 8.0mm/1.60. Three methods of measuring the area under the curve of the receiver operating characteristic curve gt; 0.7, AUCSI gt; AUCMD and AUC LD, p lt; 0.05. The conclusions of the results of the skin prick test different measurement methods cutoff for diagnosis of food allergy is not the same. Skin index the accuracy of the diagnosis of food allergy is higher than the average diameter of the longest diameter of the of food antigens rash group. The second part of three low-sensitive formula to treat infant milk protein allergy effect evaluation purposes by cow's milk protein allergy in children using three low-sensitive formulations (free amino acid formula, depth hydrolyzed formula, soy formula) treatment follow-up, assessment of each group suffering from child physical growth and improve the situation of allergy symptoms. Diagnosed as allergic to milk protein can not breastfeed infants 74 cases as the intervention group, 21 cases of healthy children as a control group. The intervention group follow the parents were given free amino acid formula principle of voluntary choice, depth hydrolyzed formula, soy formula replacement therapy. And the 1,2,3,6 a month after the start of treatment of children with medical monitoring alleviate allergic symptoms at the same time to assess the situation. The results compared with healthy children in the intervention group age weight, length and weight growth rate slows down, the growth of lower level; significant differences at follow-up three times. But found after pairwise comparison, only soy formula group and the other difference between the three groups was significant (p = 0.001); difference between the depth of the the hydrolyzed group, free amino group and the control group had no statistical significance (p gt; 0.05). Age, birth length and head circumference of age difference among the four groups were not statistically significant (p gt; 0.05). Alleviate the effects of the free amino acid formula with depth hydrolyzed formula allergy symptoms than soy formula (p = 0.003), and 1 month after treatment efficacy seen significant soy formula relieve symptoms and slow (two months later). The conclusion of free amino acid formula and depth hydrolyzed formula can maintain a milk protein allergy in children with normal physical growth, the growth rate of the treatment group of soy formula is obviously insufficient. Three can effectively alleviate the milk protein allergy in children with clinical symptoms and the free amino acid formula and depth hydrolyzed formula in the treatment of infantile eczema effect and ease the speed is superior to soy formula.

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