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Serum Cholinesterase, Platelet, Liver Fibrosis HBV Infection in Various Stages of Clinical Significance

Author: LiuQiong
Tutor: ZhuXiaoLing
School: Dalian Medical University
Course: Internal Medicine
Keywords: Chronic hepatitis B Cirrhosis Liver fibrosis Serological diagnostic criteria
CLC: R575.2
Type: Master's thesis
Year: 2011
Downloads: 3
Quote: 0
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Abstract


Objective: To study chronic hepatitis B, hepatitis B liver cirrhosis, decompensated cirrhosis, and acute hepatitis, the relationship among liver fibrosis serum cholinesterase and platelets.Methods: Retrospective study of 262 cases (including acute hepatitis, chronic hepatitis B, hepatitis B liver cirrhosis and decompensated liver cirrhosis) in patients with the information. Analysis of liver fibrosis: laminin (LN),Ⅲprocollagen (PCⅢ), hyaluronic acid (HA),Ⅳcollagen (ⅣC); liver function: cholinesterase (CHE); blood Index: platelet count (PLT). And results in chronic hepatitis B, hepatitis B liver cirrhosis, decompensated cirrhosis, acute hepatitis B were compared between the different organizations.Results: 1. HA in patients with chronic hepatitis B, hepatitis B liver cirrhosis, decompensated cirrhosis gradually increased in decompensated liver cirrhosis and chronic hepatitis B. There were significant differences between the (P <0.001). HA levels in acute hepatitis B compared with other groups no significant difference (P> 0.05). 2. PCⅢin hepatitis B liver cirrhosis was the highest, followed by chronic hepatitis B and acute hepatitis, decompensated liver cirrhosis group was the lowest. In hepatitis B liver cirrhosis group, and decompensated liver cirrhosis were significantly different between groups (P <0.05). Hepatitis B liver cirrhosis in chronic hepatitis B group and significantly different group (P <0.05). 3.Ⅳcollagen in each group were increased to varying degrees, but each group no significant difference between (P> 0.05). 4. LN in decompensated liver cirrhosis group was higher than the other three groups, but the other three groups with no significant difference between the two groups (P> 0.05). 5. CHE in decompensated liver cirrhosis was significantly lower, and with the other three groups was statistically significant difference between (P <0.005). 6. PLT in hepatitis B liver cirrhosis detected close to the normal value off the assembly line, and chronic hepatitis B group were significantly different (P <0.01), and acute hepatitis B group were significantly different (P <0.005 ); PLT in decompensated liver cirrhosis was significantly lower than normal test values, and chronic hepatitis B group were significantly different (P <0.005), and acute hepatitis B group were significantly different (P < 0.005); PLT in acute hepatitis B and chronic hepatitis B group were significantly different (P <0.01).Conclusion: 1. with the HA levels, gradually increasing the degree of liver fibrosis. 2. PCⅢsuggest active liver fibrosis, there does not reflect liver fibrosis. 3.Ⅳcollagen suggest hepatic fibrosis, but does not reflect the degree of hepatic fibrosis. 4. LN judging the degree of liver fibrosis than HA, PCⅢ,Ⅳcollagen sensitive. 5. CHE may have long-term decreased the incidence of cirrhosis. 6. platelets can be used to determine the degree of liver fibrosis is a simple, more accurate secondary method.

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CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Liver and gall bladder disease > Cirrhosis
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