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[Objective] To explore the potassium citrate on calcium into the urine of patients with upper urinary tract calculi stone risk factors. [Methods] The study included people with calcium stones in the upper urinary tract of 80 inpatient and outpatient cases, patients were randomly divided into two groups ( control group and study group ) . The control group of 40 patients , urge the water , avoid high calcium, high oxalic acid, high animal protein diet ; study group of 40 patients , in addition to avoiding high calcium, high oxalic acid diet high in animal protein and more water , the addition of citrate service potassium 2g / times , 3 times a day , continued to take two months. For selected patients after taking 24h urinary biochemical parameters were measured , analyzed before and after treatment whether there are changes in urine composition . [Results] study included 80 patients , of which 68 patients completed the study ( study group of 35 patients in the control group, 33 cases ) , study dropout rate of 15% . After two months of treatment , the study group : 24h urinary calcium increased from 5.67 ± 1.73mmol/24h dropped 3.51 ± 1.49mmol/24h (P lt; 0.05); 24 -hour urinary potassium increased from 29.53 ± 11.55mmol/24h increased to 58.96 ± 11.25mmol/24h (P lt; 0.05); 24 -hour urine oxalate decreased from 121.38 ± 107.81mmol/24h fell 59.53 ± 50.66mmol/24h (P lt; 0.05); 24 -hour urinary citrate decreased from 132.60 ± 89.70mg/24h increased to 339.84 ± 204.86mg/24h (P lt; 0.05); treatment before and after the study group of 24 -hour urinary calcium , urinary potassium , urinary oxalate , urinary citrate changes were statistically significant . The 24-hour urinary magnesium, urinary phosphorus , uric acid changes were not statistically significant (P gt; 0.05). The control group of 24 -hour urinary calcium , urinary potassium , urinary oxalate , urinary citrate and urinary magnesium, urinary phosphorus , uric acid changes were not statistically significant (P gt; 0.05). By t test, there was significant difference between two groups (P lt; 0.05). [Conclusion] potassium citrate can significantly increase urinary calcium citrate in patients with upper urinary tract stones and urinary potassium content, decreased urinary calcium and urinary oxalate concentration . Application of upper urinary potassium citrate reduced calcium stone recurrence may be associated with these factors.
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