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Assessment of Serum BNP,VEGF, and hsCRP on Congenital Systemic to Pulmonary Shunts Heart Disease with Pulmonary Hypertension

Author: ZhangChengHua
Tutor: GuangXueFeng;YinXiaoLong;PiYanSheng
School: Kunming Medical College
Course: Cardiovascular within science
Keywords: Congenital heart disease and pulmonary shunt Pulmonary hypertension Brain natriuretic peptide Vascular endothelial growth factor High - sensitivity C - reactive protein Mean pulmonary arterial pressure
CLC: R541.1
Type: Master's thesis
Year: 2009
Downloads: 71
Quote: 0
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Abstract


Objective: To investigate serum BNP, VEGF, hsCRP level and pulmonary shunt congenital heart disease and / or the relationship of the pulmonary artery pressure in patients with pulmonary hypertension, as well as in different parts of the difference to try non-invasive assessment of the degree of pulmonary artery pressure, pulmonary vascular remodeling The occurrence and mechanism of pulmonary hypertension. : Pulmonary shunt congenital heart disease in 41 cases, 20 cases of normal control group. Congenital heart disease underwent preoperative echocardiography routine examination, the the parallel right heart catheterization, based on the measured mean pulmonary arterial pressure, divided into no pulmonary hypertension in 16 cases, 13 cases of mild to moderate pulmonary hypertension and severe pulmonary hypertension group 12 cases. Take the peripheral venous and pulmonary blood 4ml, all patients with congenital heart disease which ASD patients an alternative to the pulmonary vein 4ml PDA patients an alternative to aortic blood 4ml. Control group were cubital vein 4ml. Serum specimens was measured by enzyme-linked immunosorbent assay (ELISA) BNP, VEGF, and hsCRP levels, analysis, and pulmonary vascular remodeling in patients with different degree of pulmonary artery pressure and different parts of serum analysis. Results: 1. Pulmonary shunt congenital heart disease serum of BNP, VEGF and hsCRP levels were significantly higher than the control group, and the BNP, VEGF levels and pulmonary artery pressure degree of a linear correlation. Serum BNP, VEGF levels determine pulmonary hypertension and have higher degree of accuracy. Serum BNP 2.ASD and PDA patients with pulmonary artery, pulmonary vein and aortic VEGF levels significantly higher than in the peripheral vein and the pulmonary artery, pulmonary vein and the aortic valve and no difference between; Serum hsCRP levels in the peripheral venous, pulmonary artery, no difference in the pulmonary vein and the aortic valve. 3. Pulmonary shunt congenital heart disease with pulmonary hypertension, the resistance pulmonary hypertension group serum BNP, VEGF level higher than the dynamic pulmonary hypertension group, hsCRP level was no significant difference in the two groups. 4. Cardiac Doppler ultrasound can be used as a more reliable indicator of the estimated pulmonary artery systolic pressure, pulmonary shunt congenital heart disease and mild to moderate pulmonary hypertension assessment accurate, often overestimate patients with pulmonary hypertension, severe pulmonary hypertension underestimated. Conclusion: Serum BNP, VEGF, and hsCRP levels can more accurately assess the degree of pulmonary vascular remodeling and pulmonary shunt congenital heart disease and / or pulmonary hypertension, peripheral blood cleared of BNP, VEGF levels do not reflect the real level of the pulmonary circulation, out into the lungs blood BNP, VEGF levels. Echocardiography as a more reliable indicator of the estimated pulmonary artery pressure, combined with serum BNP, VEGF level increase the pulmonary shunt congenital heart disease the pulmonary hypertension assess accuracy. The pulmonary shunt congenital heart disease and pulmonary hypertension patients activation of the inflammatory response, inflammatory reaction and VEGF may be involved in the occurrence of pulmonary hypertension.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Congenital heart disease
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