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The Experimental Influences of Baihui-Qubin Acupuncture on Interleukin-6 Expression of Rats with Intracerebral Hemorrhage

Author: KongYing
Tutor: ZouWei
School: Heilongjiang University of Traditional Chinese Medicine
Course: Acupuncture and Massage
Keywords: the rat model of acute intracerebral hemorrhage the acupuncture of BaiHui-QuBin Interleukin-6
CLC: R245
Type: Master's thesis
Year: 2009
Downloads: 32
Quote: 0
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Abstract


Objective: By observing the BaiHui-QuBin scalp-acupuncture on acute cerebral hemorrhage in the rat model of brain tissue IL-6 protein expression, to study the acupuncture on the cerebral hemorrhage secondary brain injury after the neuro protective mechanisms in order to guide clinical practice.Method: 1. Totally 60 male wistar rats were randomly allocated into four group:blank group(n=6),intracerebral hemorrhage control group(n= 18), acupuncture group(n=18), and western medicine (pisacetam) group(n = 18).2. The rat models of acute intracerebral hemorrhage were made.3. The acupuncture point: BaiHui point to QuBin point, which can penetrate three regions of the cupula and forehead and temple.4. The Berderson neural deficit scores were tested at three time points(6h,2d,7d after hemorrhage model establishment)before the rat models were killed, then the brains were removed and index were detected.5. The average gray scale of Interleukin-6 protein expression by immunohistochemical method were checked, the morphologic change on light microscope was observed.6. Statistical treatment was made.Results: 1 . The results of the neurologic deficit score of the acupuncture group is better than intracerebral hemorrhage group and western medicine group at 2 days. Acupuncture group and western medicine group were better than those in intracerebral hemorrhage group at 7 days.2. The results of masculine cell in the average gray scale ofInterleukin-6 in untreated control group is different from intracerebra-1 hemorrhage group (ICH). In 2 days, the average gray scale of Interleukin-6 in acupu-ncture group is lower than those in intracerebral hemorrhage group. There was also difference between acupuncture group a -nd western medicine group. Acupuncture group and western medicine group were lower than those in intracerebral hemorrhage group, and there was differe-nce between acupuncture group and western medicine group in 7 days.3. The results of the brain pathological change in acupun -cture group and western medicine group is different from those in in -tracerebral hemorrhage group.Conclusion: 1 . BaiHui-QuBin acupuncture can obviously raise the Berderson neural deficit scores, and have the benefit of improvement of extremity function after intracerebral hemorrhage.2. Study showed that acute phase of cerebral hemorrhage, BaiHui-QuBin scalp-acupuncture therapy can be reduced IL-6 protein expression, reduce the inflammatory response after cerebral hemorrhage caused by the extent of secondary brain injury, ischemic brain tissue in order to improve status and the protection of hypoxic injury in neurons.

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