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Preparation of Vitamin A Proliposomes and Research on Properties of Microencapsules

Author: LiuQiaoLian
Tutor: YeZhiYi
School: Chongqing University
Course: Biophysics
Keywords: Vitamin A Proliposome Microcapsules Encapsulation efficiency Stability
CLC: TQ466.1
Type: Master's thesis
Year: 2009
Downloads: 229
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Abstract


In recent years, vitamin A (vitamin A, VA) are widely used in food, cosmetics and pharmaceuticals, however, due to the vitamin A is susceptible to the influence of the environmental conditions such as light, oxygen and accelerated degradation, and its application has been limited. This study used the oil-in-water - the freeze-drying was prepared vitamin A precursor liposomes, in order to improve the stability of the vitamin A, and to make it easier storage and application. In this thesis, a precursor of vitamin A liposome preparation process, physical and chemical properties and stability studies of the Roche vitamin A microcapsules physical properties. The differences in the physical properties of the both. Moisture microcapsule product, heap, the determination of the physical properties such as density, solubility, flowability and particle size, and calculate its payload, the results show that the moisture content was 2.42% of the microcapsule product is easy to store; bulk density of 0.57 g/cm3; solubility of 89.7%, better solubility; repose angle of 37 °, good liquidity; payload of 14.00%, the largest embedded. The microcapsules had an average particle diameter of 2.05 ± 0.33μm. Soybean lecithin as the raw material, the use of oil-in-water - Homogeneous prepared vitamin A liposome, in order to improve the stability of the vitamin A liposome, using the freeze-drying method to prepare a proliposome and indicators of the encapsulation efficiency was orthogonal design was used to optimize the prescription. To obtain the optimum formulation for the phospholipid concentration of 4% VA with phospholipid ratio of 1:40, the cholesterol and phospholipid ratio of 1:8. Of the pharmaceutics Proliposome evaluate. VA liposome lyophilized morphological changes before and after. The results show that: the result of changes in particle size and distribution were 424.4 ± 99 nm, and 430.5 ± 120 nm, VA liposome lyophilized distribution increases slightly. Measured lyophilized before and after encapsulation efficiency of 83.1% and 79.8%, respectively. The stability results indicate that no significant change in the appearance of the lyophilized liposomes in the placement process, pH value is slightly increased, the average particle diameter increases slightly, the encapsulation efficiency is slightly decreased. Investigated the physical and chemical nature of the precursor liposomes results showed: VA precursor liposome hydration optical microscope showed class oval; pH value of 6.42; compatible with 5% glucose; without particle size greater than 1μm; hydration after encapsulation efficiency is essentially the same. VA proliposome investigated from two aspects of the physical, chemical stability, the results show The VA Proliposome light, thermal instability, it is recommended that the cold stored in the dark. Stored at room temperature (25 ℃), the significant improvement in the stability of the indicators; stored at low temperature (4 ℃) preparation stability requirements. Comparison is case of the microcapsule products and Proliposome physical nature. The particle size of the microcapsule product is greater than the particle size of the liposomes before; embedding rate only when a certain payload (14.00%), the other load is not large. Precursor liposome encapsulation efficiency affected by moisture, the average encapsulation efficiency was 79.8%.

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CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Vitamin manufacturing > Vitamin A
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