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The Protective Effects of Boschniaria Rossica on Atherosclerosis

Author: JinChengHai
Tutor: ChenZhengAi
School: Yanbian University
Course: Internal Medicine
Keywords: Boschniaria rossica atherosclerosis
CLC: R285
Type: Master's thesis
Year: 2008
Downloads: 63
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Abstract

Objective:To investigate the anti-atherosclerosis effects of Boschniaria rossica and its mechanism through experimental atherosclerosis model of animals,and to provide theory guidance for clinic exploitation of anti-atherosclerosis drugs.Methods:The experimental atherosclerosis model of rats were set up by feeding with atherogenic-diet and injecting vitamin D₃（150,000U/kg by intramuscular injection in right lower limb once a week）.Wistar male rats used in experiment were randomly divided into four groups:the normal group（normal diets）;model group（atherogenic-diets）;BR-treated group（atherogenie-diets +Boschniaria rossica）; SI-treated group（atherogenic-diets+Simvastain）.Boschniaria rossica and Simvastain were performed intragastric administration when atherogenic-diets were given, BR-treated group was performed intragastric administration of 160mg /kg.d Boschniaria rossica suspension,SI-treated group was performed intragastric administration of 9mg /kg.d Simvastain suspension,model group and the normal group were performed intragastric administration of the equal volume of drinking water,once a day,8 weeks in total.The level changes of Serum total cholesterol、triglyceride、low density lipoprotein cholesterol、high density lipoprotein cholesterol were measured after 8 weeks administration,the contents of malondialdehyde and the activity of superoxide dismutase in blood serum were detected.The experimental atherosclerosis model of rabbits were set up by feeding with atherogenic-diets.Wistar male rabbits used in experiment were randomly divided into four groups:the normal control group（normal diets）;model group（atherogenic-diets）; BR-treated group（atherogenic-diets +Boschniaria rossica）;SI-treated group（atherogenic-diets+Simvastain）.Boschniaria rossica and Simvastain were performed intragastric administration when atherogenic-diets were given,BR-treated group was performed intragastric administration of 80mg/kg.d Boschniaria rossica suspension,SI-treated group was performed intragastric administration of 5mg/kg.d Simvastain suspension,Model group and the normal group were performed intragastric administration of the equal volume of drinking water,once a day,8 weeks in total.The aortas of rabbits were separated,the pathological changes of aortas were observed under light microscope after HE staining after 8 weeks.Results:Compared with model group,BR could markedly decrease the total cholesterol、triglyceride、low density lipoprotein cholesterol in blood serum,which had a significant difference（P＜0.01,P＜0.01,P＜0.05）,BR could markedly increase high density lipoprotein in blood serum,which had a significant difference（P＜0.01）, BR could significantly reduced the contents of malondialdehyde in blood serum, which had a significant difference（P＜0.01）,BR could markedly enhanced the activity of superoxide dismutase in blood serum,which had a significant difference（P＜0.01）; BR could reduce endothelial cell engorgement of artery wall、arrangement derangement of smooth muscle and the histoleucocyte adhesion of atherosclerosis model rabbits.Conclusion:BR had antioxidant effect,It’ s possible mechanism could be attributed to regulating the lipid metabolism of rats,resisting the injury caused by oxidation free radical and preventing the injury of atherosclerosis artery endomembrane.

The Protective Effects of Boschniaria Rossica on Atherosclerosis

Abstract

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