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Fractional Photothermolysis for the Treatment of Striae Distensae

Author: WuZuoJie
Tutor: XuJinHua
School: Fudan University
Course: Dermatology and Venereology
Keywords: Expansion pattern Fractional Laser RCM
CLC: R758.6
Type: Master's thesis
Year: 2011
Downloads: 30
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Abstract

[Background] expansion pattern is mainly occurred in parts of atrophic body tension cord, looking for a safe and effective treatment is now the main direction of the current study. [Objective] To understand fractional laser treatment of the Chinese expansion pattern role and to find the appropriate treatment parameters, establish a reasonable treatment options to improve the efficacy and reduce the occurrence of side effects. 【Methods】 60 cases the trunk limbs expansion pattern patients were recruited, including 43 women and 17 men. Fractional laser treatment. Using random digital table were randomly divided into three groups. Divided into the control group, ActiveFX the DeepFX group. Each subject received a treatment of 1 to 3 times. Baseline, before each treatment and each visit dermatology clinicians not involved in the governance comprises three separate subjects expansion streak ratings and record digital camera and recorded the clinical response, adverse events and The subjects' self-assessment of therapeutic effect. Reflective confocal microscope (Reflectance confocal microscopy, RCM) detection of cases before treatment and after treatment of skin lesions, and two patients before treatment and after a month immunohistochemistry. [Results] 60 cases completed the treatment and follow-up. Made according to each patient at baseline and 3 months after the last treatment, follow-up evaluation found that the analysis results showed that the treatment group and the control group, the treatment group with the control group in the overall improvement in skin roughness significant difference ( P lt; 0.01). DeepFX compared with the control group, in the depth of the skin was significant difference (P LT; 0.01). To compare the efficacy ActiveFX, and DeepFX two groups and found that significant differences exist between them, and the roughness of the skin depth of two statistically significant (P lt; 0.05). The satisfaction of the patient's self-assessment results prompted the treatment group and the control group showed a significant difference (P lt; 0.01). The two groups ActiveFX with DeepFX significant difference. SD the genotyping analysis found differences between groups were statistically significant (P lt; 0.05) laser treatment on the the type Ⅰ and type Ⅵ SD of have good clinical efficacy. Treatment for 3 times the patient the best prognosis, differences exist between the groups. Treatment group compared with the control group on the pigmentation have a significant difference (P LT; 0.01). The two treatment groups the comparison down DeepFX the pain than ActiveFX significantly. RCM detection shows treatment telangiectasia, edema and inflammatory reaction can be seen in one week, one month after reticular arranged collagen fibers can be seen. Immunohistochemical results are shown SD dermal thickening after treatment organizations, telangiectasia and edema and inflammatory reaction. Collagen I and collagen III staining was positive after treatment. DeepFX methods are better than those in the overall improvement in skin roughness and depth evaluation ActiveFX. Patient satisfaction is the satisfaction of self-evaluation results suggest that the treatment group were higher, which DeepFX treatment of patients with the highest satisfaction. The clinical efficacy of laser treatment of type Ⅰ and type Ⅵ SD. Treatment three times the patient the best prognosis, side effects evaluation, the the ActiveFX, and DeepFX visible mild pigmentation performance the DeepFX pain than ActiveFX the obvious. The lattice laser can be a safe and effective treatment expansion pattern.

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