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The Utilization of the Realtime Fourier-domain Anterior Segment OCT (FD-OCT) in the Image and meVinsanteurement of Schlemm’s Canal and the Diagnosis of Primery Open Angle Glaucoma

Author: WangFei
Tutor: JiangChunZuo
School: Fudan University
Course: Ophthalmology
Keywords: OCT Schlemm's Previous section Angle Scleral Glaucoma Intraocular pressure Gonioscopy Intraocular pressure Schwalbe Normal people Iris root Trabecular meshwork Permeability anterior glaucoma Cornea domain Subjects Aqueous humor
CLC: R775
Type: Master's thesis
Year: 2011
Downloads: 42
Quote: 0
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Abstract


Primary open-angle glaucoma is a serious threat and damage to the optic nerve visual function main pathological intraocular pressure associated clinical syndrome, its etiology is complex. Glaucoma clinical manifestations of diversity, the accuracy and variability of the means of diagnosis may become the cause of the misdiagnosis. To find a good repeatability, convenient operation aided diagnosis of glaucoma, disease diagnosis, treatment and follow-up has a great significance. Optical coherence tomography (optical coherence tomography) since its birth, has many applications in the field of ophthalmology. Accompanied in the anterior segment applications to expand and further development of the technology, the fourth generation of the Fourier domain (Fourier domain FD) OCT in terms of resolution, imaging speed, tissue penetration than the previous time-domain (Time domain, TD ) OCT has increased significantly, it has a high-resolution, high penetrating angle imaging features that make it aroused extensive attention of researchers in Schlemm's tube (Schlemm's canal) imaging and measurement applications. Commercial anterior segment OCT penetration difference (840-870nm scanning light source) or low resolution (time domain) problem, and yet on the application of Fourier domain OCT observe normal subjects with primary open-angle glaucoma patients Schlemm's tube differences and normal human Schlemm's tube correlation between changes with intraocular pressure of 24 hours of research. Therefore, the use of custom-1310nm Fourier domain real-time imaging of the anterior segment OCT imaging of the anterior segment of the instrument used in Schlemm's tube imaging and biological measurements study selected patients with primary open-angle glaucoma, select both normal as controls, clear normal human Schlemm's canal shape and area of ??the biological parameters; primary open-angle glaucoma angle imaging, compared with age-matched normal population study differences in patients with normal population Schlemm's tube; 24 hours of normal human intraocular pressure angle imaging, to study the relationship between the Schlemm's tube and intraocular pressure circadian variation and both. The results show that the real-time Fourier-domain anterior segment OCT tube cross-section of Schlemm's clear imaging and precise measurement can intuitively reflect Schlemm's tube circumstances. Has a good prospect as a non-invasive non-contact, easy-to-check method, real-time Fourier-domain anterior segment OCT diagnosis in primary open-angle glaucoma.

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CLC: > Medicine, health > Ophthalmology > Intraocular pressure and glaucoma
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