Dissertation > Excellent graduate degree dissertation topics show

Effects of Sevoflurane and Propofol on Heart Rate Variability During Induction of Anesthesia in Elderly Patients with Coronary Artery Disease

Author: OuXiaoFeng
Tutor: ZhengHong
School: Xinjiang Medical University
Course: Anesthesiology
Keywords: Propofol Sevoflurane Coronary artery disease Induction of anesthesia Heart rate variability
CLC: R614
Type: Master's thesis
Year: 2011
Downloads: 19
Quote: 0
Read: Download Dissertation


Objective:To investigate the effects of sevoflurane and propofol on cardiovascular response and heart rate variability(HRV) during induction of anesthesia in elderly patients with coronary artery disease. Methods:Forty ASAⅡ~Ⅲpatients with coronary artery disease aged 60-80yrs weighing 45-80kg, scheduled for elective surgery were randomly divided into sevoflurane group(S group,20 cases) and propofol group(P group,20 cases). ECG、invasive BP、HR and HRV were monitored before and during induction of anesthesia. Patients in group S inducted by inhaling sevoflurance with 4% concentration until falling into sleep and then fentanyl 3ug/kg and vecunium 0.1mg/kg intravenous injection. In group P, the target controlled induction concentration of propofol was 3 ug/ml until the patients went into sleep and then followed by administration of fentanyl 3ug/kg and vecunium O.lmg/kg. All these drugs were injected by vein. The changes of hemodynamics and HRV were observed at the time points of before induction(baesline), and 5min, 10min,15min,20min after induction. Side effects such as chest wall rigidity、hypotension and the uses of any vasoactive drugs were also recorded. Results:There were no statistical differences between the two groups with respect to sex、age、weigh、height、type of operation、preoperation blood pressure、HR and HRV、In S group the SBP、DBP、HR were significantly lower than the baselinet at the time points of 5min, 10min after induction(P<0.05),in P group the SBP、DBP were significantly lower than the baseline at the time points of 5min, 10min,15min after inductio(P<0.05). The SBP、DBP in group P were significantly lower than those in group S, but the HR was significantly higher in group P. After the induction of anesthesia, the low frequency(LF) was mainly decreased in a time-depended manner in S group, significantly lower than the baseline at the time point of 5min、10min、15min(P<0.05), but not at the time point of 20min; while the high frequency(HF) was no significant difference between the time points and the baseline; LF/HF was significantly lower than the baseline only at the time point of 15min(P<0.05). In P group, LF was significantly lower than the baseline only at the time point of 5min(P <0.05); HF was mainly decreased in a time-depended manner, significantly lower than the baseline at all the time points(P<0.05); LF/HF was significantly higher than the baseline at the time point of 10min、15min,、20min(P<0.05).The incidences of side effects such as chest wall rigidity、hypotension and the uses of any vasoactive drugs were no significant difference between the two groups. Conclusion:Propofol mainly inhibits cardiac parasympathetic nerve system, while sevoflurane might reduce cardiac sympathetic tone more than parasympathetic tone and would maintain hemodynamics during the induction of anesthesia in elderly cornary heart disease patients, so, induction of anesthesia with sevoflurane is beneficial to elderly cornary heart disease patients. There is no remarkable difference in cardiovascular response induced by propofol and sevoflurane during tracheal intubation.

Related Dissertations

  1. Medical interventions for patients with chronic heart failure heart rate variability,R259
  2. The Efficacy Comparing of Sufentanil and Fentanyl Assisted by Propofol for Aponia Colonoscopy,R614
  3. The Clinical Values of 64-slice Spiral Computed Tomography Angiography to Coronary Artery Stenosis,R541.4
  4. Half-effective Target Plasma Concentration of Remifentanil Tci for Intubation during Inhalational Induction with 1.3MAC Sevoflurane,R614
  5. Ankle-brachial index combined ultra- sensitivity C-reactive protein determination of the value of coronary artery disease,R541.4
  6. Propofol on rat thalamocortical loop GABA_A Receptor of,R965
  7. Study of Quality Control of 64-slice CT Coronary Angiography in Diagnosis of Rheumatic Heart Disease Abstract,R816.2
  8. The Characteristics of Coronary Angiography in Type 2 Diabetes Mellitus Patients with Suspected Coronary Artery Disease,R587.1
  9. The Mechanisms of Propofol-induced Relaxation on Isolated Thoracic Aorta Rings in Rats,R614
  10. Effects of Propofol on the Apoptosis and Activation of NF-κB in Polymorphonuclear Neutrophil in Acute Lung Injury Induced by LPS in Rats,R965
  11. The Changes and the Clinical Significance of Serum Ischemia Modified Albumin, Soluble Intercellular Adhesion Molecule 1 and C-reactive Protein in Patients with Coronary Heart Disease,R541.4
  12. Design Research on Portable Sleep Monitoring Instrument,R318.6
  13. Clinical Studies on the Neuroprotective Effect of the Propofol in Patients after Acute Traumatic Brain Injury,R969
  14. Effects of Propofol on Lung Injury Induced by Hepatic Ischemia Reperfusion in Rats,R965
  15. Comparison of Sevoflurane and Propofol in Patients Undergoing Aneurysm Clamping Operations,R614
  16. The Effects of Dexmedetomidine on Target-controlled Infusion of Propofol and Stress Reaction for Laparoscopic Cholecystectomy,R614
  17. The Influence of Different Doses of Dexmedetomidine on Hemodynamic and Effect of Propofol Given by Target-controlled Infusion,R614
  18. Application of Sevoflurane Anesthesia in the Cardiopulmonary Bypass,R614
  19. The Effect of Menstrual Cycle on the Dose of Propofol in Induction of General Anesthesia,R614
  20. Effects of Different Dosage Propofol on Serum NO and NOS Expression in Tissue by Intermittent Intraperitoneal Injection in Rats,R614

CLC: > Medicine, health > Surgery > Surgical operation > Anesthesiology
© 2012 www.DissertationTopic.Net  Mobile