Dissertation > Excellent graduate degree dissertation topics show

The Main Pharmacodynamic Study on Radix Bupleuri and Radix Scutellare in Compatibility

Author: ChenHuiHui
Tutor: LiGuiHai
School: Shandong University of Traditional Chinese Medicine
Course: Of Pharmacy
Keywords: Compatibility of herb-partners Radix Bupleuri Radix Scutellariae Anti-pyretic and Anti-inflammatory Cholagogic Action Chemical liver injury Experimental Study
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 48
Quote: 0
Read: Download Dissertation

Abstract


Objective:To review the anti-pyretic and anti-inflammatory effects of Radix Bupleuri and Radix Scutellare in different compatibilities,and elucidate the relationship of compatibility and pharmacodynamics;To observe the effect on bile secretion of rats administered by Radix Bupleuri and Radix Scutellare in compatibility,and look for the best proportion on Cholagogic Action;To Review the effect of Radix Bupleuri and Radix Scutellare in compatibility on hepatic injury by CCl4,and elucidate the relationship of compatibility and pharmacodynamics further.Methods:Testing medicine of 1g/ml in accordance with the ratio 1:0,1:2,1:1,2:1,0:1 of Radix Bupleuri and Radix Scutellariae were prepared.We built rat febrile models with 2,4-dinitrophenol and dried yeast respectively and models of swelling ear in mice with mixed liquid induced inflammation.Researchers observed effects of the five testing medicine on rat febrile models and models of swelling ear in mice;Researchers detected choleresis and calculated bile-body weight after administered and formed fistula in surgery three hours,detected and compared the amount of total bilirubin,direct bilirubin and cholesterol in bile;The effects of five testing medicine on main indicators,such as liver index,biochemical indicator,histopathology and immunohistochemistry,were detected in acute hepatic injuried mouse models by CCl4 .Results:Compared with the blank,the effect of the testing medicine in different compatibility ratio on rat febrile model by 2,4-dinitrophenol is that Radix Bupleuri:Radix Scutellariae 1:2 and 0:1 had statistical significance,and the other three groups have no obvious statistical significance.But the effect of the testing medicine in different compatibility ratio on rat febrile model by dry yeast is that Radix Bupleuri:Radix Scutellariae 1:1,0:1 and 1:2 had obvious statistical significance while the other two had no effect.Radix Bupleuri:Radix Scutellariae 0:1 and 1:2 groups had an obvious effect while the other three groups had no effect compared with the blank on tumfaction degree of mice’s ears and the swelling rate;Compared with the blank,Radix Bupleuri:Radix Scutellariae 0:1 and 1:1 group had the most choleresis,1:2 and 2:1 group followed,1:0 group had no significant difference.The levels of total bilirubin,direct bilirubin and cholesterol in each drug administration group were changed in different degree;The pharmacodynamic effects of the testing medicine in different compatibility ratio was different in all investigations of hepatic injury.Radix Bupleuri:Radix Scutellariae 1:2 had the strongest hepatoprotective effect,Radix Bupleuri:Radix Scutellariae 0:1 followed while the 1:0 group had no significant conservancy effect on hepatic injury.Conclusion:The testing medicine in different compatibility ratio has different effect size on the anti-pyretic and anti-inflammatory effects,cholagogic action and hepatoprotective effect.The best compatibility ratio is different in rat febrile models caused by two pyrogen.Radix Bupleuri:Radix Scutellariae 1:2 has the strongest effect on rat febrile model by 2,4-dinitrophenol while 1:1 on rat febrile model by dry yeast.The anti-inflammatory effects are mainly related to the amount of Radix Scutellariae in compatibility;The best compatibility ratio is between Radix Bupleuri:Radix Scutellare 1:2 and 1:1 on cholagogic action;The pharmacodynamic effects of the testing medicine in different compatibility ratio are different in all investigations of hepatic injury.Radix Bupleuri:Radix Scutellariae 1:2 has the strongest hepatoprotective effect,Radix Bupleuri:Radix Scutellariae 0:1 followed,while the 1:0 group had no significant conservancy effect on hepatic injury.That indicated Radix Scutellariae had the main hepatoprotective effect in compatibility,but the effect is stronger after compatibled with Radix Bupleuri.

Related Dissertations

  1. Experimental Study of GUI QIN MISTURE on Adriamycin-induced Nephropathy in Rats,R285.5
  2. Gas and coal dust explosion characteristics of coexistence and Communication Research,TD712
  3. The Use of Incentive Strategies on the Study of the Impact of Sports Participation in Primary School Physical Education,G623.8
  4. The Theoretical and Experimental Research on the Collocated MIMO Detection,TB566
  5. Design and Experimental Study of High Performance Miniature Channel Heat Sinks,TK124
  6. Shandong Institute of Physical Education Teaching and Training Basketball physical experimental study,G841
  7. Catalytic reduction of nitrogen oxides of iron Experimental Study,X701
  8. Water pump corrosion properties of metallic materials,TG174.3
  9. Research on the Dynamic Characteristics of High Speed Solenoid Valve for ABS,U463.526
  10. The Study on the Pavement Performance of "East Sea" 90#A Asphalt for Tarim Branch of China Petroleum & Chemical Corporation,U414
  11. Stop bone hyperplasia pills experimental rabbit knee osteoarthritis morphological changes,R274.9
  12. Experimental Study and Chemcal Kinetics Molding of Advanced Pulverized Coal Reburning No Reduction,TQ534.9
  13. Numerical Investigation on the Aerodynamics and Infrared Radiation Characteristics of 2-dimensional Nozzles with Sheltering Baffles,V231.1
  14. The Designed of the Small Type of Separate Wheel Potato Digger,S225.71
  15. The Effect of Jianxizhuanggu Medication on Apoptosis of Cartilage Cells and Regulation of Gene Expression P53 and Bcl-2 in Rats with Knee Osteoarthritis,R285.5
  16. Study on Digitized Fingerprints of Radix Scutellariae,R284
  17. Research on the Effect of the Immune Function of Muice by Different Indicators of Exogenous Pathogens,R221
  18. Experimental Research on "Competition Method" of Basketball Teaching of Girls in Vocational Colleges,G841
  19. The Control and Research on Planar Wire-driven Parallel Mechanisms,TP242
  20. Experimental Research on Mixing Parameters of the Paired Mixing Arms for Twin-shaft Mixer,TQ051.72

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
© 2012 www.DissertationTopic.Net  Mobile