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Extraction and Purification of Efficacy Substances in Panax Notoginseng and Combinations of Drugs is Found in a Preliminary Study for Anti-Alzheimer’s Disease

Author: ZhengDePeng
Tutor: TianJingZhen
School: Shandong University of Traditional Chinese Medicine
Course: Of Pharmacy
Keywords: PNS Ginsenoside Rb1 Ginsenoside Rg1 technical study Alzhei-mer’s disease
CLC: R285
Type: Master's thesis
Year: 2011
Downloads: 85
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Abstract


Taking the Panax notoginseng as raw material, the extraction、purification、decolorization of PNS and the separation and purification has of monomer ginsenoside Rb1 and Rg1 have been systematically studied. At the same time exploratory studying on the improvement effect of the monomer ginsenoside Rb1 and Rg1 combination compatibility drug to animal pharmacological models of Alzheimer’s disease.Through access to relevant literature, the HPLC determination method of the PNS and its monomer has been established. the optimum technology of alcohol extraction and accumulation purification of PNS has been selected.And decolor the PNS by ion exchange resin.the purity of PNS products is about 90% . And then by silica gel column chromatography, recrystallization, The final purity of ginsenoside Rb1 and Rg1 is more than 90% .To provide the basis for production of The PNS and its monomer.By studying the compatibility drugs of ginsenoside Rb1 and Rg1 in different ratio on the improvement effect to the model of ischemia reperfusion injury cerebral and impairment of memory acquisition mice caused by anisodine, Determine the optimum ratio of compatibility drug of the ginsenoside Rb1 and Rg1 and prove its dose-effect relationship may exist between compatibility ratio and efficacy . This research provides the basis for clinical research.

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