Dissertation > Excellent graduate degree dissertation topics show

Study on Chemical Constituents and Bioactivity of Two Kinds of Coral from the Dongshan Island

Author: CuiPing
Tutor: GaoQiPin；LuYaNan
School: Changchun University of Traditional Chinese Medicine
Course: Pharmacy
Keywords: Astrogorgia dumbea Dendronephthya sp. Chemical Constituents Steroid Saponins Cytotoxic Activity
CLC: R284
Type: Master's thesis
Year: 2011
Downloads: 15
Quote: 0
Read: Download Dissertation

Abstract


Purpose: To study the chemical constituents of gorgonian Astrogorgia dumbea and soft coral Dendronephthya sp. collected from the Dongshan island of East China Sea, and research the cytotoxic activitiy of some compounds isolated from gorgonian A. dumbea.Method: The chemical constituents of A. dumbea and D. sp.were obtained by the methods of extraction, recrystallization, column chromatography and semi-preparative HPLC, etc. Their structures were elucidated by the spectroscopic methods (1D, 2D-NMR; EI-MS, HR-ESI-MS; IR, UV, etc.).Result: Twelve compounds were isolated from the MeOH and CHCl3 extractions of A. dumbea. And the structures of nine compounds (see Fig. 1) were identified as dimorphoside A (LAD-01), astrogorgiaside A (LAD-03), astrogorgiaside B (LAD-04), astrogorgiaside C (LAD-05), astrogorgiaside D (LAD-07), astrogorgiaside E (LAD-09), astrogorgiaside F (LAD-10), astrogorgiaside G (LAD-11); and batilol (LAD-12). The others were still under indentifying.Four compounds were isolated from the n-BuOH and CHCl3 extractions of soft coral D. sp.. Two of them were identified as pregna-1,20-dien-3-one (LSC-04) and pregna-1,4,20- triene-3-one (LSC-06), respectively (see Fig 2). The others were still under indentifying.The cytotoxic activity of some compounds isolated from gorgonian A. dumbea was tested. All tested compounds have cytotoxic activity against Bel-7402. At the same time, dimorphoside A and astrogorgiaside A have activity against HL-60; and astrogorgiasides B and C have cytotoxic activity against K562.Conclusion: Most of compounds from A. dumbea were steroid saponins which astrogorgiasides A-G of them are novel compounds. Dimorphoside A and batilol were first isolated from Astrogorgia species. Two pregnane compounds from D. sp., LSC-04、LSC-06, were isolated from this species firstly.

Related Dissertations

  1. The Chemical Constituents of Bryozoan Bugula Neritina L. and Junceella Fragilis from South China Sea,R284
  2. Chemical Studies on the Roots and Rhizomes of Helleborus Thibetanus,R284
  3. Study on the Chemical Constituents and Bioactivities of Acalypha Brachystachya and Daphne Genkwa,R284
  4. Phenotypic and Functional Study of NK and γδT Cells in Malignant Pleural Effusion,R730.4
  5. Study on the in Vitro Caco-2 Cells Inhibiting Active Parts and the Quality Standard of Cynomorium Songarium Rupr,R284
  6. P19-19 and TPF-4 marine actinomycete secondary metabolites,R284
  7. Studies on the Chemical Constituents of Viburnum Foetidum Var. Ceanothoides and Viburnum Odoratissimum Var. Awabuki,R284
  8. Syntheses, Structures and DNA-binding Properties of N, N’-bis (N-hydroxyethylaminopropyl) Oxamide Bridged Polynuclear Complexes,O621.13
  9. Study on Evaluation of the "Pride" Brand about Major Tobacco Leaf Quality,S572
  10. Interactions Between Bm-mesenchymal Stem Cell from Acute Leukemic Children and Natural Killer Cell from Cord Blood： Evidence in Vitro and Vivo,R733.71
  11. Studies on the Fat-soluble Chemical Constituents of Scorpion,R284
  12. The Processing Research of RADIX CURCUMAE,R283
  13. Studies on Chemical Constituents of Strychnos Nux-Vomica,R284
  14. Chemical Constituents of Dodonaea Viscosa, an Afforestation Species,R284.1
  15. Studies on the Active Fraction of Danggui Shaoyao San,R284
  16. Natural active products methyl original dioscin derivatives synthesis and biological activity research,R284
  17. Effect of Film Uncovering and Earth-up Method on Growth and Chemical Element of Flue-cured Tobacco,S572
  18. Analysis on the Physics and Chemistry Character of Flue-curing Tobacco Leaves in Baoshan County,S572
  19. Antioxidant Activity of cinnamon , cassia twig, bay leaf oil extraction process, the chemical composition and its ethanol extract,R284
  20. Secondary Metabolites of Aspergillus Ochraceus Associated with Dichotella Gemmacea under Biomimetic Culture,R284

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Traditional Chinese medicine chemical
© 2012 www.DissertationTopic.Net  Mobile