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Experiment Research of Bushentianjingfang Effect on Hemopoietic Progenitor Cell CFU-GM、CFU-E in Mice with Aplastic Anemia

Author: GuoChunHua
Tutor: DanLiJuan
School: Xinjiang Medical University
Course: Chinese medical science
Keywords: Aplastic anemia Bushentianjing Recipe Experimental study
CLC: R259
Type: Master's thesis
Year: 2011
Downloads: 25
Quote: 0
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Abstract


Objective: To observe Bushentianjing fine herbs aplastic anemia mouse model of bone marrow hematopoietic stem / progenitor cell proliferation , bone marrow pathology and peripheral blood cells , and to explore the mechanism of action of Bushen Recipe treatment of aplastic anemia . Methods: Adult male mice by intraperitoneal injection of cyclophosphamide and subcutaneous injection of benzene oil modeling species , intragastric administration Bushentianjing Jing Fang suspension 35 days after orbital action / venous blood assay peripheral red blood cells (RBC), hemoglobin ( Hb ) , white blood cell ( WBC ) , the amount of platelet ( PLT ) , and the mice were sacrificed to take the preparation of the femur bone marrow nucleated cell suspension have nuclear cells ( BMNC ) count , methyl cellulose semi-solid and cultured erythroid progenitor cell colony ( CFU -E) and granulocyte - macrophage colony ( CFU - GM ) and counted to observed Bushentianjing fine aplastic anemia mouse model of hematopoietic progenitor cells ; mice were sternal bone marrow hematopoietic tissue embedded in paraffin were observed case . Results: Bushentianjing Jing Fang , the high-dose group mice RBC , HB , WBC , PLT compared with the model group increased , was statistically significant ( P lt ; 0.05 ) ; low side Bushentianjing , medium and high dose groups BMNC increase in CFU-E and CFU - GM number compared with the model group , these indicators there are differences between the high-dose group and middle dose group and was statistically significant ( P lt ; 0.05 ) , the high dose group , middle dose group showed no difference ( P gt ; 0.05 ) ; bone marrow pathology : model mice bone marrow cavity filled with adipose tissue , hematopoietic structural damage , Bushentianjing Jing Fang group of fat cells decreased significantly , three-line cell proliferation , and more significant in the high-dose group . Conclusion: Bushentianjing before the bone marrow hematopoietic stem / progenitor cells CFU - GM , CFU - E proliferation , repair the hematopoietic tissue structure , and enhance the role of peripheral blood cells play a role in hematopoietic stem / progenitor cells .

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CLC: > Medicine, health > Chinese Medicine > TCM Internal Medicine > Modern medicine, internal diseases
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