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Objective: study the Marrow of CD34 cells were grown in the artificial blood vessel serum 6-k-PGF1α and TXB 2 changes, and its neointimal hyperplasia and thrombosis relationship. 12: Select mongrel dogs, according to the artificial blood vessel divided into of ePTFE vascular experimental group (4) and polyester vascular experimental group (4) and the ePTFE control group (2) and the polyester control group (2), canine collected from bone marrow extracted CD34 the cell seeding coated artificial blood vessels, control dogs using simple autologous blood pre-setting artificial vascular surgery vascular implants the inferior vena cava and abdominal aorta with a dog. Preoperative and postoperative 3 days, 7 days, 14 days, 30 days, 60 days femoral vein blood was measured platelet serum PGF1α of TXB 2 concentration and PGF1α/TXB 2 2 concentration first increased and then decreased and maintained at a certain level, the control group significantly increased and maintained at a high level; (4) experimental first and then decreased serum P / T ratio was significantly decreased and remained at a low level; (5) 60 days to obtain all of the artificial blood vessel specimens, the control group, neointimal obvious proliferation compared to the experimental group and thrombosis. Conclusion: (1) bone marrow CD34 stem cells to grow artificial blood vessels for vascular replacement can inhibit platelet adhesion and aggregation and activation, inhibition of growth factors, cytokines, adhesion molecules, chemokines and other bioactive chemicals produced; (2) bone marrow CD34 stem cells to grow artificial blood vessels used in vascular replacement earlier generation of artificial blood vessel lumen endothelial cells, and vascular endothelial cells produce prostacyclin, adenosine nitric oxide, VEGF and other biologically active substances, in order to effectively suppress the of PGF1α and P / T ratio excessive reduce excessive rise of the TXB 2 and platelets, further inhibition of intimal hyperplasia and thrombosis .
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