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Objective: With the progress of the cause of improving the quality of life and health, life expectancy is significantly longer, the proportion of elderly surgical patients increased with the proportion of the elderly population and a corresponding increase. As the physiological function of the elderly was the aging sexual dysfunction, decreased tolerance to anesthesia often appear the hemodynamic sharp fluctuations, fluctuations in blood pressure of more than 30% of the resting state the postoperative cardiovascular events of Risk rate can be significantly improved hemodynamic stability of the anesthesia in elderly patients is how to maintain the important issues faced by the anesthesiologist. Shenfu injection has significantly enhanced myocardial contractility, increased cardiac output, increase blood pressure, commonly used in the clinical treatment of hypotension. This topic were observed in elderly surgical patients, the Shenfu injection 1ml · kg -1 10min pre-injection before anesthesia, to explore Shenfu Injection on the blood pressure of elderly patients anesthesia. Methods: This study is a randomized, controlled study. Patient inclusion criteria: select older than 60 years old, weight 40 7 0 kg, the the the cardiac function I I grade I, normal liver and kidney function, no long-term use of analgesic, sedative drug history, drug allergies, to be under general anesthesia for elective surgery in elderly patients, 68 patients, 31 males and 37 females. Were randomly divided into a the the Shenfu group (n = 35) and the control group (n = 33). Exit criteria: surgical blood loss greater than 300ml or implementation of controlled hypotension in patients. All patients underwent preoperative conventional fasting drink 12h, premedication: Penehyclidine 0.4mg intravenous bolus before induction of anesthesia. The burglary after the establishment of intravenous access to enter the compound Ringer lactate infusion rate of 10 1 2ml · kg -1 · h -1 . Continuous electrocardiogram (ECG), noninvasive blood pressure (NIBP), pulse oximetry (the SpO 2 ), bispectral index (bisectral index, BIS) monitoring. Shenfu group before the induction of anesthesia, intravenous injection of 1ml · kg -1 Shenfu injection, injection finished 10min underwent induction of anesthesia. Two groups of patients induced by drugs: propofol 1 2 mg · kg -1 , fentanyl 2μg · kg -1 atracurium ammonium 0.5 mg · kg -1 , the BIS value fell to 40 6 0 endotracheal intubation, pick the Ohmeda-7100-type the anesthesia machine control breathing, tidal volume 8ml · kg < sup> -1 . Maintenance of anesthesia: continuous infusion of propofol 4 6 mg · kg -1 · h -1 , atracurium 5 1 0μg · kg -1 · min -1 , remifentanil 0.1 0 .2 μg · kg - 1 · min -1 to maintain anesthesia, the BIS value 40 6 0. Intraoperative continuous input compound Ringer lactate and / or poly gelatin peptide infusion rate of 10 1 2ml · kg -1 · h -1 < / sup>, crystal gel ratio of 1:1. OUTCOME MEASURES: The two groups of patients burglary (T 0 ), immediately before intubation (T 1 ), intubation after 1min (T 2 ), intubation 5min (T 3 ), stopping narcotic drugs (T 4 ), unplug the endotracheal tube immediately (T 5 ) the BIS, NIBP, heart rate (HR), SpO 2 values. Above values ??every 5min during surgery, heart rate less than 55 beats / min intravenous atropine 0.2mg, systolic blood pressure less than 90mmHg or lower than 20% of the underlying value as hypotension, intravenous injection of ephedrine 10mg. Results: 1 T 1 point in time Shenfu of SBP higher than T 2 T 5 point in time the SFI group SBP , DBP, MAP lower than the control group, the difference was statistically significant (P lt; 0.05). 2 SFI group T 2 , T 5 point in time SBP, DBP, the MAP increased close to T 0 (P gt; 0.05) . 3. Frequency SFI group of patients, hypotension occurred, and ephedrine, atropine frequency lower than the control group, but no statistical significance (P gt; 0.05). Conclusion: before induction of anesthesia in elderly surgical patients pre-injection of Shenfu Injection, two-way regulating blood pressure to a certain extent.
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