|
Objective: To investigate the relationship of type 2 diabetic retinopathy and serum lipids and insulin resistance. Method: 1. Study: Select from July 2007 to January 2008 in the Department of Endocrinology, Second Affiliated Hospital of Shanxi Medical University hospital in patients with type 2 diabetes, a total of 49 cases, including 23 males and 26 females, aged 40 years old to 89 years old. Are in line with the 1999 WHO diagnostic criteria for diabetes. Exclude the following patients: (1) acute metabolic disorders: such as ketoacidosis, hyperosmolar coma; (2) liver and kidney dysfunction; ③ original hair or secondary hypertension; the ④ monocular or binocular refractive media turbidity, affecting the fundus observation ; ⑤ severe heart failure, cancer and so on. 2 groups: type 2 diabetes without retinopathy (NDR) group is divided according to the presence or absence of retinopathy and retinopathy severity, background retinopathy (BDR) group and proliferative retinopathy (PDR) group. 3 Methods: Retrospective analysis of the first collection of patients admitted to hospital laboratory markers. Fasting for 12 hours early in the morning venous blood were detected by fasting glucose (fasting plasma glucose, FBG), true insulin (true insulin, TI), glycosylated hemoglobin (glycosylated hemoglobin A 1 c, HbA1c), triglycerides the ester (triglycerid, TG), total cholesterol (total cholesterol, TC), high density lipoprotein cholesterol (high density lipoprotein cholesterol, HDL-C), low-density lipoprotein (low density lipoprotein cholesterol, LDL-C), apolipoprotein A (apolipoproteins a ApoA) and apolipoprotein B, (apolipoproteins b, APOB). Insulin sensitivity index (ISI). All patients underwent fundus examination the consultation record) (according to the ophthalmologist. Results: (1) the use of Kruskal-Wallis rank sum test, three groups of FBG, TI, HbA1C, ISI, TG, LDL, APOA difference was statistically significant (P = 0.012,0.025,0.000,0.002,0.001,0.012,0.000) . TC, HDL and apoB was no significant difference (P = 0.492,0.052,0.112). 2.BDR group with the NDR group, the BDR group of TG and LDL were higher than the NDR group (P <0.05), and the rest of the indicators was no significant difference. 3.PDR group and the NDR group, HbA1c, FBG, TI, TG and LDL were significantly higher (P <0.05), TG difference significant (P <0.01), the APOA and ISI was significantly lower (P <0.01). Groups 4.PDR BDR group, HbA1C was significantly higher (P <0.01), the ISI significantly reduced (P <0.01). The rest showed no significant difference. 5. Correlation analysis showed that diabetic retinopathy and TG, LDL-C, TI was a significant positive correlation with apoA, the ISI was a significant negative correlation, the conclusion: group of 1.PDR and BDR group and NDR group, TG and LDL There are significant differences, and the PDR group was the most significant difference. Correlation studies have shown that diabetic retinopathy and TG, LDL-C was significantly positively correlated, suggesting that lipid abnormality and the occurrence and development of diabetic retinopathy. The 2.BDR group and the NDR group ISI no difference, but the PDR group and the NDR group ISI and PDR group and the the BDR group of ISI have significant differences. Correlation studies have shown that diabetic retinopathy and fasting insulin was significantly positively correlated with insulin sensitivity index was significantly negatively correlated, suggesting the occurrence of insulin resistance and diabetic retinopathy, related to the development.
|