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In order to find the insecticidal activity, in line with the requirements of the 21st century pesticide development of new nicotine insecticidal lead compounds, commercialization thiamethoxam, imidacloprid structural modification, designed and synthesized a formula for (I) and (II) two series of a total of 37 compounds not been reported. (1). Guanidine nitrate as a starting material, followed by electrophilic substitution, Manich condensation, nucleophilic substitution, such as multi-step reaction synthesis of the 13 not been reported in the literature 1 - thiazol-methyl-5 - alkyl-1 ,3 5 - hexahydro-triazin-2-N-nitro-imine derivatives (Ⅰ a ~ Ⅰ m). (2) the nitroguanidine and various amino acids as a starting material, after acylation, esterification, Manich condensation, nucleophilic substituted reaction multi-step synthesis of 24 were reported in the literature has an optically active 1 - thiazole ( pyridyl) methyl-5 - the ethoxycarbonyl hydrocarbon ,3,5 - hexahydro-triazin-2-N-nitro-imine derivative (II a to Ⅱ x). NMR, EI mass spectrometry, ESI mass spectrometry, elemental analysis, infrared spectroscopy, specific rotation of the two series of compounds to characterize the structure and its physical properties, spectral properties, reaction conditions, synthesis method systematic analysis and discussion. More in-depth understanding of the compound space structure, preliminary exploration of compound structure and the nature of the relationship, this thesis, the series (Ⅰ) and (Ⅱ) part of the compound, and compound (Ⅰ i), compound (Ⅱ a) and compound (Ⅱ p) conducted a single crystal culture and X-ray diffraction crystal structure determination, to obtain a single (S) compounds of the configuration, and conducted a preliminary analysis of the structure and activity. Target compound (I), (II) the formula is as follows: the target compounds in the series (I) and (II) the determination of the insecticidal activity of commissioned bioassay Ministry of National Southern Pesticide Research Center, Zhejiang base. Determination show that the series (Ⅰ) (Ⅱ) the part of the target compounds of armyworms have better inhibitory activity, series (Ⅱ) the activity is good in the series (Ⅰ), which the target compounds Ⅱ g m Ⅱ, Ⅱ w, Ⅱ x in 50ppm concentration armyworm inhibition rates were 80%, 90%, 80%, 80%. Preliminary interpretation of the insecticidal activity of the target compounds at the molecular level, the target compound molecular acetylcholinesterase receptor docking, analysis of the role of the target molecule in the active site of acetylcholinesterase receptor, in order to explain The objective compound insecticidal activity differences.
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