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AMACR and PSCA in prostate cancer tissues and its clinical significance

Author: LiZheng
Tutor: BaiXianZhong
School: Guangxi Medical University
Course: Department of Urology
Keywords: Prostate Cancer AMACR PSCA Immunohistochemistry
CLC: R737.25
Type: Master's thesis
Year: 2010
Downloads: 53
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Abstract


Objective: To detect α-methyl acyl coenzyme A racemase (α-methyl-acyl-coenzyme A racemase, AMACR) and prostate stem cell antigen (Prostate stem cell antigen, PSCA) in prostate cancer and benign prostatic hyperplasia tissue case analysis AMACR and PSCA in prostate cancer tissues and pathological grade and clinical stage relationship between AMACR and explore PSCA in prostate cancer tissues and its clinical diagnosis and prognosis value. METHODS: August 2005 - December 2009 Affiliated Tumor Hospital of Guangxi Medical University, Department of Urology inpatient prostate pathology specimens 55 cases, including 25 cases of prostate cancer, benign prostatic hyperplasia, 30 cases. Without preoperative radiotherapy and chemotherapy. All specimens were fixed in formalin and embedded in paraffin. Retrospective analysis of clinical data through the medical records of patients obtained pathological data were re-stained with HE jointly by the two clinical pathologists read the film won. Immunohistochemical SP method detected 55 cases of prostate cancer and benign prostatic hyperplasia and PSCA AMACR expression. Drawing table, using SPSS16.0 statistical package for the chi-square test and Pearson correlation analysis of both expression and clinical and pathological features relationships. Results: AMACR in prostate cancer, the positive expression group was 80% (20/25), the positive rate in prostate hyperplasia 0% (0/30), AMACR in prostate cancer tissues was significantly higher than the abnormal benign prostatic hyperplasia tissue (P lt; 0.05). PSCA in prostate cancer positive expression group was 100% (25/25), the positive expression rate of benign prostatic hyperplasia group was 83.3% (25/30). PSCA in prostate cancer and benign prostatic hyperplasia group, no significant difference in positive rate (P gt; 0.05). Analysis of PSCA in prostate cancer and benign prostatic hyperplasia group strongly positive expression rate of prostate cancer group 64% (16/25), benign prostatic hyperplasia group 33.3% (10/30), the difference was statistically significant (P lt; 0.05) . AMACR expression intensity with prostate cancer pathological grade (Gleason grade) are related. (P lt; 0.05). The strength of PSCA expression with prostate cancer pathological grade (Gleason grade) did not show any significant correlation. AMACR with no obvious clinical stage correlation with clinical stage and PSCA has a relatively significant correlation (P lt; 0.05). AMACR and PSCA also found in both prostate cancer and benign prostatic hyperplasia expression had no significant correlation. Conclusion: 1, AMACR in most prostate cancer specimens expressed prostatic hyperplasia in no expression, suggesting that AMACR is both high sensitivity and specificity of tumor markers. 2, PSCA in prostate cancer group was significantly higher than the strong positive prostatic hyperplasia and prostate cancer in clinical stage PSCA expression of strength and a relatively clear correlation, suggesting that PSCA on prostate cancer diagnosis and prognosis of a certain value. 3, the joint AMACR with PSCA diagnosis of prostate cancer can improve the diagnostic sensitivity.

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Male genitalia tumors > Prostate cancer
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