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Solanesol is an unsaturated polyisoprene polyol, because the molecule contains a plurality of non-conjugated double bonds, has a very strong absorption performance radical, itself has anti-bacterial, anti-inflammatory and hemostatic effect, it is important pharmaceutical intermediates, when connected to many drugs solanesol long chain alkenyl group can be made for some of the excellent performance of the new drugs. Solanesol mainly used for the synthesis of vitamin K2, anticancer drugs, anti-ulcer drugs, cardiovascular disease and anti-aging drugs coenzyme Q10, which is particularly important as the main raw material for the production of coenzyme Q10. Coenzyme Q10 is most commonly used in medicine cardiovascular disease prevention and treatment of cancer and viral hepatitis have a certain effect in the world, has a broad market demand. Accordingly, the domestic and international markets for crude solanesol content of 90% or more solanesol great demand, the market prospect is broad. Boutique solanesol from 2004 global demand soared, prices soaring, but fine (content gt; 90%) solanesol production is very difficult, technical threshold is too high, the current domestic manufacturers capable of producing very little, causing Boutique solanesol mainly rely on imports, the price is too high. Coenzyme Q10 is also a direct result of high prices. In this thesis, preparation of high purity (70% active ingredient and 90%) of fine solanesol for the purpose of solving industrial production problem of high cost, through small scale experiments to explore the boutique solanesol preparation process, research suitable for industrial mass production methods and the optimum conditions. (A) investigate the extraction agent, extraction times, crushed tobacco leaves concentrated manner solanesol extraction effect. Experimental results show that the highest rate of 100% methanol extract, extraction times is 4 times, each time 1.5h. The extract was concentrated to 83% -85% alcohol level, the active ingredient can be fully extracted solanesol, recovery rate of 98%, the mother liquor residue ≤ 1.5%. (2) for crude solanesol saponification and extraction can be removed acids, aldehydes and other fats and oils ingredients to make solanesol freed, played a separation and purification purposes. (3) with petroleum ether, methanol, methanol / acetone (5:1) mixture as solvent, respectively solanesol crude product purified by crystallization. Methanol - acetone mixed solvent crystallization effect is ideal. Crystals after recrystallization using active carbon can be obtained for 78% meet the requirements for medicinal solanesol. (4) HPD100 macroporous resin adsorption capacity, selectivity, adsorption and desorption under mild conditions and other characteristics. Its for the separation medium, can well be a low content of solanesol was purified with a purity of 91.67% of the product. Liquid solvents, analytical liquid methanol concentrations were affecting the adsorption effects and resolve the important factors. (5) in a small test on the basis of experiments to determine the crushed leaf extracts from solanesol pilot production process, including solanesol extraction, concentration, saponification, extraction, crystallization, adsorption and other processes. Process analysis critical control points, made a budget on production costs. Choice of production processes and conditions pollution, waste treatment easier, lower cost, without using large high-tech equipment, can generally be applied to SMEs.
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