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Studies on the Effect of Sodium Arsenite on the Migration and Proliferation of HUV-ECs Its Mechanism

Author: LvHui
Tutor: LiRongGui
School: Jilin University
Course: Pathology and Pathophysiology
Keywords: Sodium arsenite HUVECs Migrate Proliferation FAK C-MYC MMP-9
CLC: R114
Type: Master's thesis
Year: 2010
Downloads: 80
Quote: 0
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Abstract


Hundreds of millions of people around the world exposed to high arsenic environment , many of them concentrated in East Asia , China is one of the countries with the most serious hazards of arsenic . Over the years studies have shown that peripheral blood vessels is a major target organ of arsenic cytotoxicity . Vascular endothelial cells lining the blood vessels within the surface of simple squamous cells , the normal function of peripheral vascular exercise depends on the maintenance of the integrity of the vascular endothelial injury promptly repaired . Vascular endothelial cells play a decisive role in this process . For the study of the molecular mechanism of the the arsenide damage repair function of vascular endothelial cells and its role , the application of cultured human umbilical vein endothelial cells ( Human YANBIAN UNIVERSITY. Protective effects of the compound Danshen vein endothelial cells HUVECs), as the vascular endothelial cells in vitro experimental models through the cells damage repair assay and cell proliferation assay of sodium arsenite on cell migration and cell proliferation . The results showed : sodium arsenite significantly inhibited the migration and proliferation of vascular endothelial cells . Moreover, the concentration of both sodium arsenite significant dose - effect relationship , that is, the greater the dose , the stronger the inhibition of cell migration and proliferation . Table Minya sodium arsenite to damage its vascular repair function by inhibiting vascular endothelial cell migration and proliferation rate . This article further analysis at the mRNA level of sodium arsenite on cell migration and proliferation gene expression , found that sodium arsenite inhibit FAK and C-MYC gene expression , respectively, in view of the two - gene product of the migration and proliferation of endothelial cells play an important role , suggesting that inhibition of this gene expression are important molecular mechanism of sodium arsenite inhibits vascular endothelial cell migration and proliferation . In addition, it also found that sodium arsenite can increase the expression of MMP-9 gene , suggesting that this gene also lowering associated with endothelial cell migration . Arsenic disease of the results of this study, the molecular mechanism of vascular injury provides a new interpretation and provide a new basis for ground arsenic disease prevention and treatment .

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