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The purpose of neonatal hypoxic-ischemic myocardial injury (hypoxic-ischemic myocardial, HIM) is the serious complications associated with perinatal asphyxia. Recent studies show that glycogen phosphorylase isoenzyme cerebral (glycogen phosphorylase isoenzyme BB, GPBB) can be used as a sensitive marker of early diagnosis of myocardial injury, but very little in neonatal myocardial damage. In order to learn more about the merger changes in myocardial injury the GPBB asphyxia, in this experiment determined asphyxia plasma GPBB the level, at the same time analysis with a variety of perinatal factors, to provide a theoretical basis for early clinical diagnosis and treatment . Randomly selected 64 cases of asphyxia as the object of study (39 cases of mild asphyxia, severe asphyxia in 25 cases, 30 cases of myocardial injury, non-cardiac injury, 34 cases), 25 patients with no history of asphyxia and cardiovascular diseases, neonatal the control group. Measured by enzyme-linked immunosorbent assay (ELISA) plasma GPBB levels, enzymes, troponin I, ECG, X-ray detection. Results of myocardial injury in children plasma GPBB of level (13.84,7.57) ng / ml was significantly higher than that of non-myocardial injury group (4.97,3.24) ng / ml and the control group (4.95,1.99) ng / ml (P lt; 0.01) ; non-myocardial injury group GPBB level with the control group, the difference was not statistically significant (P gt; 0.05) 2, GPBB, cTnI, CK-MB sensitivity of the diagnosis of myocardial injury, respectively, for 90%, 66.7%, 83.3%, The GPBB sensitive than cTnI (x2 = 4.812, P lt; 0.05), compared with the CK-MB significant difference (Chi-square = 0.577, P gt; 0.05); GPBB cTnI, CK-MB specificity for the diagnosis of myocardial injury, respectively, to 88.2%, 91.2%, 67.6%, specificity of GPBB better than CK-MB (x2 = 4.191 , P lt; 0.05), compared with the cTnI was no significant difference (x2 = 0.159, P gt; 0.05) 3, severe asphyxia group plasma GPBB of level (14.67,6.09) ng / ml and mild asphyxia group (5.61,3.56) ng / ml and the control group (4.95,1.99) ng / ml were significantly higher (P lt; 0.01 ); the mild group GPBB level compared with control group increased slightly, but the difference was not statistically significant (P gt; 0.05) 4, the plasma the level of GPBB and sheep degree of water pollution was positively correlated (r = 0.500, P lt; 0.001); Apgar scores were negatively correlated (r = -0.520, P lt; 0.001); gender, gestational age, birth weight, birth , placenta, umbilical cord and other factors had no significant correlation (P gt; 0.05) Conclusion neonatal asphyxia myocardial injury in children the plasma GPBB level significantly increased, and GPBB change and the degree of asphyxia is closely related to the more severe the higher the level of suffocation. Of meconium, Apgar score and the level of asphyxia plasma GPBB of correlation, suggesting that fetal distress and the degree of asphyxia and neonatal hypoxic-ischemic myocardial injury related. Therefore, asphyxia determination of GPBB level of early detection of myocardial injury, and help determine the severity and degree of suffocation clinical diagnosis and treatment.
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