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Objective: To explore a simple high-fat diet and simple food restriction on serum adiponectin, leptin, soluble leptin receptor and related indicators. Methods: 21-week-old male SD rats were randomly divided into a control group (C group), diet restriction group (R) and the high-fat group (H). Control group a normal diet feeding high fat rats given a high-fat diet feeding, food restriction group was given a limit of 20% of the energy of ordinary forage. Keeping weekend, 16 rats were measured weight, height, obesity evaluation index (Lee), perirenal fat, epididymal fat, serum adiponectin (Adipo), leptin (Leptin) soluble leptin receptor (sLR), cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and lipoprotein lipase (LPL) and hepatic lipase (HL) indicators. Results: ① obese rats weight, perirenal fat and epididymal fat weight was significantly higher (P lt; 0.01), but lower than that of the control diet restriction group rats' weight, perirenal fat and epididymal fat around the weight group (P lt; 0.05). Group of food restriction and high-fat rats Lee's index and the control group, there were significant differences (P lt; 0.01); (2) food restriction group Adipo significantly higher than that of the control group (P lt; 0.01), high-fat group Adipo significantly lower than the control group (P lt; 0.01). ③ diet restriction group Leptin significantly lower than the control group (P lt; 0.01), the high-fat group Leptin was significantly higher than that in the control group (P lt; 0.05); the limit food group sLR significantly higher than those in the control group (P lt; 0.01) The fat group sLR significantly lower than the control group (P lt; 0.05). ④ limited fresh serum TG, TC, LDL-C were significantly lower than those in the control group (P lt; 0.01), the high-fat group TG, TC, LDL-C were significantly higher (P lt; 0.01); diet restriction group, compared to the high-fat group, serum HDL-C with the control group no significant difference (P gt; 0.05). (5) food restriction serum lipoprotein lipase (LPL) LPL significantly higher than the control group (P lt; 0.05), the high-fat group was significantly lower than the control group (P lt; 0.05); diet restriction group liver esterase (HL) significantly lower than the control group (P lt; 0.05), the high-fat group was significantly higher than that of the control group (P lt; 0.05) HL. Conclusion: ① high-fat diet alone, can be effective to increase the weight of the experimental rats, significantly increased rat serum the LP concentrations reduce serum sLR concentration, reduce the concentration of serum Adipo cause hyperlipidemia, the formation of obesity. ② limit of 20% pure energy intake in the diet, and can effectively reduce the weight of the experimental rats, significantly reduce the concentration of serum Lp increase serum sLR concentration, increased serum Adipo concentration, and improved experimental rat lipid levels, limiting The incidence of obesity. (3) high-fat diet alone and simply limit of 20% of energy intake diet can significantly affect the serum HL active, suggesting that changes in diet can affect the esterase activity, thereby affecting the level of serum lipids.
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