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Role of ibuprofen - phenanthroline synthesis of metal complexes , antibacterial and protein

Author: ZhangYanJun
Tutor: CaoXiaoFeng
School: Shanxi Medical
Course: Medicinal Chemistry
Keywords: Ibuprofen Phenanthroline Transition metal Rare earth metals Complexes Bacteriostatic Bovine serum albumin
CLC: O621.13
Type: Master's thesis
Year: 2010
Downloads: 129
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Abstract


Ibuprofen (ibuprofen) tradename Fenbid, is a non-steroidal anti-inflammatory drugs, which have good pharmacological activity and characteristics, coupled with its structure containing the functional group - carboxyl group having a good coordination ability, solid and attracted many Bioinorganic scholars sight. The main subject of study of ibuprofen - phenanthroline transition metal (Zn, Co) and rare earth complexes, and its characterization; study the antibacterial activity of the synthesized complexes with cloth ibuprofen inhibition capacity compared; using UV spectroscopy and fluorescence spectroscopy to study the interaction between the complexes with bovine serum albumin. Thesis consists of the following parts: Synthesis and Characterization of an ibuprofen - phenanthroline transition metal (Zn, Co) and rare earth metal complexes of this subject first synthesis of ibuprofen (ibp) - phenanthroline phenanthroline (phen) a transition metal (Zn, Co) and rare earth metals (La, Ce, Pr, Nd, Sm, Gd, Dy, Er, Ho) complexes, and studied its physicochemical properties. By elemental analysis, IR, NMR, DTA - TGA and conductivity and other methods were used to characterize the synthesized complexes speculated, based on the results of the characterization of the composition of the complexes: transition metal (Zn, Co) M (ibp exactly what physiological activity) 2phen · H2O; rare earth complexes RE (ibp) 3phen. two synthetic antibacterial activity of the complex study of ibuprofen to form complexes to its physiological activity discussed the subject with simple operation, low cost, the effect is obvious inhibition zone test, determination of the antibacterial effect of the synthesis of ibuprofen - phenanthroline transition metal (Zn, Co) and rare earth metal complexes. The results showed that the synthesis of complexes have some inhibitory effect on Staphylococcus aureus and Bacillus subtilis, the antimicrobial activity of the rare earth metal complexes than Zn, Co complexes, all complexes of Staphylococcus aureus and Bacillus The antibacterial activity of the bacilli are stronger than the corresponding ligand ibuprofen and phenanthroline, suggesting that ibuprofen and Zn, Co, and rare earth metals synergies, so that the antibacterial ability. The three series of complexes with bovine serum protein interactions using UV spectroscopy and improved fluorescence spectroscopy to study the synthesis of complex interactions with bovine serum albumin (BSA). 1 UV spectroscopy using UV difference spectroscopy. Found, by detecting the with BSA added complexes characteristic absorption spectra were obvious changes: UV absorption at 200nm-226nm intensity gradually weakened with increasing BSA; 226nm near peaks disappears; located 232nm drastically reduced absorption intensity of the characteristic peaks in the vicinity, and the wavelength is moved to the longer wavelength direction; regularity of the absorption intensity at 264nm at rendering enhancement. Described complexes with BSA was a significant interaction to form a complex, thereby causing complexes microenvironment polarity change. 2 Fluorescence Spectrometry complexes have the fluorescence absorption, in order to exclude the fluorescence of the complex interference absorption on the experimental results, it is the present experiment using the background fluorescence deduction method. The experimental results show that with the increase of complex concentration, the fluorescence intensity of BSA is gradually decreased, suggesting that complexes of BSA quenching effect. Before and after the complex was added, the BSA maximum emission at a wavelength of the fluorescence intensity ratio F0 / F [Q] plotting, can initially determine the complexes of BSA fluorescence quenching process is static quenching. Lg [(F0-F) / F] = lg [K] n lg [Q] equation, the number of binding sites and the binding constant of each compound was determined. The synchronous fluorescence judge complexes with BSA binding region. Studies show that the complexes can be combined with plasma albumin, for temporary storage, and thus may be serum albumin transported to the target organ, thus making it possible to prolong the action time of the complexes and increase efficacy, can be inferred that the synthesized as a possible drug complexes and the possible ways and the basis for further development and the biological activity of the Institute of synthesis complexes.

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CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Theory of organic chemistry,physical organic chemistry > Organic Chemistry Structure Theory
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