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Role of Tissue Factor on Oxaliplatin Inhibits Invasion and Induced Apoptosis in Human Gastric Cancer Cell

Author: GuoChao
Tutor: CaoNong
School: Lanzhou University
Course: Surgery
Keywords: Tissue factor Stomach tumor Gastric cancer Oxaliplatin Attack Apoptosis
CLC: R735.2
Type: Master's thesis
Year: 2010
Downloads: 19
Quote: 0
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Abstract


[ Background] stomach (gastic cancer) on top of the list of a variety of malignant tumors incidence postoperative metastasis and recurrence rate. Oxaliplatin (Oxaliplatin, OXA) is a third-generation platinum anti-cancer drug , is widely used in the chemotherapy of gastric cancer . Studies have shown that tissue factor is not only widely expressed in normal human cells , and high expression in a variety of tumor cells , and play an important role in the invasion and metastasis of tumor cells . [ Objective] To observe tissue factor (tissue factor, TF) OXA inhibition of human gastric cancer cell invasion and apoptosis of human gastric cancer cells . [ Method ] using recombinant TF-pcDNA3.1 ( experimental group) has been successfully transfected with empty vector pcDNA3.1 ( control group ) in human gastric cancer cell line SGC7901 incubated together with OXA . Using Transwell chamber observed changes in cell invasion , using a colorimetric assay Caspase-3 activity using the WST-1 assay to detect the cytotoxicity of oxaliplatin . [Results] the two sets of cell invasion force the Transwell chamber of the experimental group at the bottom of polyester film surface nuclei of more than the control group , P < 0.05 , the two groups of Caspase -3 activity comparison experimental group Caspase-3 activity was lower than control group , P < 0.05 cytotoxicity results of the experimental group cells survival rate higher than that of the control group , P <0.05 . [Conclusion ] the TF increased expression can reduce OXA inhibition of gastric cancer cells in vitro invasion weakened OXA induced apoptosis .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Gastric neoplasms
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