Dissertation > Excellent graduate degree dissertation topics show

Characteristics and Clinic Research of Vestibular Evoked Myogenic Potential

Author: WuBing
Tutor: JiXiaoLin；ZhouRuiLing
School: Fujian Medical
Course: Neurology
Keywords: Vestibular evoked myogenic potential VEMP Position Acoustic stimulation Benign positional vertigo Vestibular dysfunction
CLC: R764
Type: Master's thesis
Year: 2008
Downloads: 70
Quote: 0
Read: Download Dissertation

Abstract

Objective: To compare the different gender, different ages, different position and different stimulation patterns induced vestibular evoked myogenic potential to explore the factors that affect the vestibular evoked myogenic potential for vestibular myogenic evoked potential response characteristics, the establishment of the laboratory control parameter values; and by observing benign positional vertigo, cerebellar infarction and pontine infarction in patients with vestibular evoked myogenic potential changes to investigate the diagnostic value of clinical vertigo disease. Subjects and Methods: The study subjects: 65 healthy adults (subjects were divided into three groups, the first group: 20 to 40 years, 10 males and 10 females, a total of 20 people; Group II: 41 to 60 years, 13 males and 11 females, a total of 24 people; Group III: 61 years, 11 males and 10 females, a total of 21), 25 benign positional vertigo, 12 cerebral infarction, 6 pontine infarct patient's test results for the clinical study. Test method: brainstem evoked potential (IHS SmartEP, ASSR) were studied. Vestibular evoked myogenic potential study different position, the test involves two positions: supine pillow looked up bit and seat turned. Test in this study are sitting turned away: supine pillow payable to bits: the subjects supine to underlay a pillow in the patient's head, the patient's head left the pillow, so that the plane of the bed of the patient's occipital plane into an angle of about 30 °. Sitting turned: Participants take seats, side of the sound recording, the head of the subject as much as possible torsional contralateral shoulder to reach the observer visible the SCM side edge level. Detection method through the surface of the recording electrode placed in the middle of the bilateral sternocleidomastoid calibration headset monaural stimulation to sound the same side of the record, the contralateral white noise shielding. Short beeps: sparse wave the short sound 0.1ms, short sound intensity: 100 dBnHL. Short pure tone: the tone burst strength 100dBnHL, frequency 500Hz, up and down the platform to 4ms. Two modes of stimulation the same settings: each sound stimulation rate 5 times / sec, analysis time: 100 ms. Stacks up to 200 times each stimulus; Recorder: EMG signal gain of 1000, the band-pass filtering the range of 30 to 3000Hz. Recording time: to sound to sound 80ms. Two waveforms can be repeated as the standard. Pole resistance lt; 3 ohms. Results: 1. Vestibular evoked myogenic potential response characteristics: no significant difference (P gt; 0.05) 1.1 each group of male and female subjects latency and amplitude. Different age groups vestibular evoked myogenic potential incubation period was no significant difference (P gt; 0.05) The different ages amplitude were significantly different (P lt; 0.05), age and amplitude was negatively correlated (the left and right side of the amplitude of the correlation coefficients were -0.581 and -0.631, are lt; 0). Healthy people left and right ears difference results: left and right ears incubation period was no significant difference; amplitude of the left and right ears there is no obvious difference was statistically significant. Rate of 1.2 leads to: the rise - turned to the order, he turned - made payable to the order of two sequence, beginning with the rise-bit (100%) and is turned away (85%), the latter leads to rate decreased significantly (P lt ; 0.05). Incubation period: the rise - turned to order: the rise of bit measured P13, N23 incubation period, the incubation period measured and turned and bit a significant difference (P lt; 0.05) Turned - made payable to the order, the incubation period was no significant difference. Incubation period were not significantly different (P gt; 0.05) between the two positions peak. Amplitude: in the header - turned to the order, the relative amplitude ratio was 0.53 (P lt; 0.05). Turned - made payable to the order, the relative amplitude ratio was 1.13 (P GT; 0.05) 1.3 short sound vestibular evoked myogenic potential lead-out rate of 98%, short pure tone leads to 88%, a significant difference (P lt; 0.05) between the two. Short sound incubation period is shorter than the incubation period of the tone burst, both statistically significant difference (P lt; 0.05) Short sound amplitude ratio of the amplitude of the tone burst (P lt; 0.05) 2 vestibular evoked myogenic potential clinical application: 2.1 benign positional vertigo patients with a total of 50 ears, 30 of the affected ear and 20 normal ear involved in detection. 30 affected ear, the eight affected ear P13 latency, the remaining 22 affected ear P13 latency within the normal range. P13, N23 latency than the normal control group values ??are slightly extended, compared with the normal group, there was no significant statistical significance (P gt; 0.05) Patients with benign positional vertigo peak incubation period to be significantly lower than the normal group (P = 0.014). 9 out of 30 affected ear reduce the peak-to-peak asymmetry between ipsilateral and health ear, reduce the degree of normal control group peak-to-peak amplitude asymmetry rate compared statistically different (P = 0.012) . 2.2 All cerebellar infarction and pontine infarct subjects induced vestibular evoked myogenic potential. The incubation period of cerebellar infarction and pontine infarction subjects with normal control group was not significantly different (P gt; 0.05). The amplitude of the observed damage and contralateral side there was no statistical difference compared with the normal group (P gt; 0.05); the ear asymmetry rate compared to the normal value was not statistically significant (P gt; 0.05). Conclusion: 1. Vestibular evoked myogenic potential response characteristics: 1.1 Gender does not affect the vestibular evoked myogenic potential latencies and amplitudes. Age does not affect the incubation period. Was negatively correlated with age and amplitude. Increase with age, its amplitude. Between the left and right ears of the normal population vestibular evoked myogenic potential latency, amplitude difference was not statistically significant. Can help to make the side of the lesion. The involvement of the side of the vestibule, non-lesion side parameters can be used to evaluate the lesion side. Bilateral display involvement should take into account the influence of age. 1.2 supine pillow looked up and bit seat turned leads to high amplitude, short incubation period. 1.3 short sound compared with tone burst rate, leads to a short incubation period and amplitude. Vestibular evoked myogenic potential clinical application: 2.1 vestibular evoked myogenic potential provides a new method of diagnosis for the diagnosis of benign positional vertigo. 2.2 cerebellar infarction does not affect the vestibular evoked myogenic potential parameters. The pontine infarction does not affect the vestibular evoked myogenic potential parameter changes.

Characteristics and Clinic Research of Vestibular Evoked Myogenic Potential

Abstract

Related Dissertations