Dissertation > Excellent graduate degree dissertation topics show

The Expression of GDNF and It’s Receptors in the Salivary Adenoid Cystic Carcinoma

Author: WangJun
Tutor: GuoXinCheng
School: Central South University
Course: Clinical Stomatology
Keywords: GDNF GFRα-1 RET MEC penneural invasion immunohistochemistry
CLC: R739.8
Type: Master's thesis
Year: 2008
Downloads: 88
Quote: 0
Read: Download Dissertation

Abstract


Objective:To study the expression of glial cell line-derived neurotrophic factor(GDNF)and GDNF receptors(GFRα-1、RET)in salivary adenoid cystic carcinoma(SACC)and explore it’s relationship with the clini-pathological features and biological behavior of SACC.Materials and Methods:1.10 normal parotid gland、36 salivary adenoid cystic carcinoma (SACC)and 15 Mucoepidermoid carcinoma(MEC)were selected. Clinical information was collected including patient age,location, pathological type,perineural invasion and clinical stage et al.2.Using immuohistochemical SP staining,we examined protein GDNF and it’s receptors expression in paraffin slices of 36 salivary adenoid cystic carcinoma.As control,expression of these proteins in 15 MEC and 10 normal parotid gland were also detected.3.Difference of GDNF and it’s receptors were analyzed in normal parotid gland、MEC and SACC.Relationships of these proteins expressiom with clini-pathological parameter were analyzed in SACC.Rresult:1、In the gland alveolus cells of normal parotid gland,GDNF and it’s receptoe didn’t express;In the ductal cells of normal parotid gland,the positive expression rate of GDNF is 50%(5/10),the positive expression rate of GFRα-1 is 40%(4/10).RET didn’t find positive expression. 2、In the SACC,the positive expression rates of GDNF is 88.9%(32/36);the positive expression rates of GFRα-1 is 83.3%(30/36); Expression of GDNF and GFRα-1 had no correlation with location, pathological type(P＞0.05),But it had correlation with clinical stage and perineural invasion(P＜0.05),And seven cases of strong positive expression,their GDNF expression had a weakening trend from the nerve to peripheral carcinoma.3、In the Mucoepidermoid carcinoma,GDNF and RET didn’t express;the positive expression rate of GFRα-1 is 40.0%(6/15).4.The positive expression rates of GDNF and GFRα-1 has statistical significance between the SACC、Mucoepidermoid carcinoma and normal parotid gland.Conclusions:1、In the normal parotid gland and Mucoepidermoid carcinoma, GDNF and GFRα-1 didn’t exoress or had a poor expression,however,In the SACC,GDNF and GFRα-1 expressed significantly;GDNF and it’s receptor may be as one of the biological signs with perineural invasion of SACC.2.GDNF and GFRα-1 may play an importent role in the infiltration and perineural invasion of SACC.

Related Dissertations

  1. Roles of MMP-7 and Lysozyme in the Pathogenesis of Ulcerative Colitis Induced by DSS in Balb/c Mice,S858.91
  2. The Study of Kisspeptin/GPR54 System on the Reproductive Regulation in the Hen’s Hypothalamus-Pituitary-Ovary Axis,S831
  3. Study on the Digestive Tube During the Embryonic Stage of Gushi Chicken,S831
  4. A Comparative Study of prawns, crabs, Spiroplasma disease immunohistochemistry and pathology,S945
  5. Expression of WW Domain Containing Oxidoreductase Gene in Cholangiocarcinoma and Its Effect on the Biological Behavior of Cancer Cell Line QBC939,R735.8
  6. Expressions of PRL-3 and p27 in Gastric Carcinoma and Their Clinical Significance,R735.2
  7. Expression of hnRNP A2/B1 and p21WAF1 Proteins in Lung Cancer and Their Clinical Significance,R734.2
  8. The Effects of RIP on the Immune Function of Renewal Rats Without Colostrums,S853.7
  9. Study on the Expression and Correlation of Metallothionein and Matrix Metalloproteinase-2 in Non-small Cell Lung Cancer,R734.2
  10. Expression and Their Significance of Apoptosis Regulatory Factors Survivin、XIAP and c-Jun、NF-κB in Epithelial Neoplasm of Ovary,R737.31
  11. Expression and Clinical Significance of Survivin and YAP in Cervical Carcinoma,R737.33
  12. Expression and Clinical Significance of PTEN and Caspase-7 in Gastric Cancer and Precancerous Lesion,R735.2
  13. Cloning and Expression Analysis of NCCRP-1 AND IL-10 Genes in Grass Carp (Ctenopharyngodon Idellus),S917.4
  14. Expression and Antibody Preparation of sglt1 from Cyprinus CarpioL.,S917.4
  15. The Effect of Hepatic Denervation on Liver Regeneration after Partially Hepatectomy in Rats,R363
  16. Expression and Correlation of Caspase-3 and Cx43 in Myocardial Infarction with Different Narrow Degree Coronary Artery,R542.22
  17. The Expression and Relationships of Bmi-1 and c-myc in Diffuse Large B-cell Lymphoma Tissues,R733.1
  18. Expression of Caspase-4 and Caspase-3 Gene Related Apoptosis in Pathological Changes of Sternocleidomastoid of Congenital Muscular Torticollis and Four Years Clinical Followed-up for Opereated Patients,R726.8
  19. The Feasibility of the Immunohistochemistry Classification to Predicting Prognosis in Breast Cancer,R737.9
  20. Expression Characteristics and Clinical Significance of RECK in Cervical Cancer,R737.33
  21. Study on Expression of Minichromosome Maintenance Proteins2、7 in Primary Squamous Cell Carcinoma and Cervical Intraepithelial Neoplasia and Its Significance,R737.33

CLC: > Medicine, health > Oncology > Oral cavity, maxillofacial tumors
© 2012 www.DissertationTopic.Net  Mobile