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Objective: To investigate heme oxygenase -1 (heme oxygenase-1, HO-1) in the DA to Lewis rat model of acute rejection in liver transplantation , its acute rejection after liver transplantation impact , and to explore the protective effect of possible mechanisms . Methods: DA to Lewis rat liver transplantation model of acute rejection were divided into three groups , each with 12 pairs. A group of donors 24 h before surgery intravenously 5ml/kg saline as a control ; B group donor 24 h before surgery meridians dorsal penile injection HO-1 inducer cobalt protoporphyrin (CoPP), C group donor to give HO-1 inhibitor zinc protoporphyrin (ZnPP), subject to the same treatment continued after transplantation until death receptors postoperative 7 days , 6 of each group were sacrificed , peripheral blood and liver samples of serum ALT, DBIL level, organizations pathological rejection level , RT-PCR and Western-blot method for the determination of graft within the HO-1 mRNA, Foxp3 mRNA and protein expression , I observed survival. Results: After 7 days , B group blood ALT, TBIL level with group A , C group, the difference was statistically significant (P <0.01); pathology showed graft rejection in group B was mild in A, C group ; group B, HO-1, Foxp3 mRNA and protein expression were stronger than a, C group ; B group recipient survival time (29.83 ± 1.40d) than group A (13.00 ± 0.52d, P = 0.000 <0.01) and C group (11.67 ± 0.42d, P = 0.001 <0.01) was significantly longer , and a, C no statistically significant difference between groups (P = 0.67> 0.05). Conclusion: HO-1 induction of liver transplantation sustained high expression within the graft by promoting enhanced expression of FoxP3 play immunosuppression , reduce acute rejection after liver transplantation .
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