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Objective: To observe the aconite Guizhi compatibility of adjuvant arthritis in rats ( Adjuvant Arthritis AA ) analgesic , anti-inflammatory , anti-free radical damage to prove the compatibility of the two drugs can enhance the analgesic , anti-inflammatory , the role of anti-free radical damage , and to find out the optimal analgesic , anti-inflammatory , anti-free radical injury compatibility proportion . Methods: SD rats were randomly divided into normal group, model group , Tripterygium glycosides , aconite group , Gui group , aconite Guizhi 9:4 , Aconite Guizhi 3:2 group of seven groups of 10 each only . In addition to the normal group , and the remaining rats in each group in the right rear paw pad subcutaneous injection of Freund's complete adjuvant (Freund's Complete Adjuvant, FCA) 0.1ml, AA rat model . The single herb aconite , Gui and compatibility between the two 9:4 and 3:2 ratio made ??of decoction gavage treatment, observe their pain threshold of AA rats , paw thickness and serum nitric oxide ( Nitricoxide , NO ) , superoxide dismutase ( superoxide dismutase SOD ) , the malondialdehyde ( Malodialdehyde MDA ) content . Results: (1 ) monkshood, Guizhi different compatibility proportion at different times of the day has improved to some extent AA rats pain threshold , reduce the the AA rats swelling paw thickness of a single application compatibility of the two drugs efficacy Fuzi or Guizhi Fuzi Guizhi , 9:4 improve the role of AA rats pain threshold , aconite the Guizhi 3:2 reduce swelling paw thickness of . (2) the monkshood, Guizhi its compatibility proportion have a role in reducing inflammation serum NO and MDA , but aconite Guizhi efficacy 9:4 ; lesions increased SOD activity , single flavor Gui sticks no effect, single herb aconite to enhance the efficacy of SOD activity , but not as good as its compatibility group the aconite Guizhi 9:4 efficacy , compatibility group the most significant . Conclusions: (1 ) of aconite with Guizhi compatibility of the anti - inflammatory , analgesic, anti-free radical damage has significant synergies , reveals \(2) analgesic , anti-free radical damage induced by compatibility proportion with aconite Guizhi 9:4 ; play the best compatibility proportion of the anti-inflammatory effects of aconite Guizhi 3:2 .
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